DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
FAM27E3
UniProt ID:
Q08E93
Entrez ID:
Protein name:
Protein FAM27E3
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
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for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
FAM27E3
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.R27C
DO225345
BRCA
ICGC
LHTPKAE
DEG_SCF_FBW7_2
19:25
Mutation rewiring degron network
0.2778
p.R27C
DO218863
SKCA
ICGC
LHTPKAE
DEG_SCF_FBW7_2
19:25
Mutation rewiring degron network
0.2778
p.T33I
DO229353
LAML
ICGC
LHTPKAE
DEG_SCF_FBW7_2
19:25
Mutation rewiring degron network
0.1111
p.R11S
DO232519
PBCA
ICGC
LHTPKAE
DEG_SCF_FBW7_2
19:25
Mutation rewiring degron network
0.1111
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for FAM27E3 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc