DegronMD - Q08ET2(SIGLEC14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H207N	TCGA-44-3396	LUAD	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation rewiring degron network	0.2778
p.H207N	DO23559	LUAD	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation rewiring degron network	0.2778
p.P202H	TCGA-49-AAR4	LUAD	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation altering degron motif	0.7694
p.P202H	DO218920	LUAD	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation altering degron motif	0.7694
p.T209I	TCGA-56-A62T	LUSC	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation rewiring degron network	0.2222
p.T209I	DO219144	LUSC	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation rewiring degron network	0.2222
p.G208A	TCGA-66-2767	LUSC	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation rewiring degron network	0.25
p.G208A	DO26713	LUSC	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation rewiring degron network	0.25
p.P202T	TCGA-67-3770	LUAD	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation altering degron motif	0.7031
p.P202T	DO23932	LUAD	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation altering degron motif	0.7031
p.D206N	TCGA-DX-A8BP	SARC	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation rewiring degron network	0.3056
p.D206N	DO220056	SARC	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation rewiring degron network	0.3056
p.S196L	TCGA-EE-A2MR	SKCM	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation rewiring degron network	0.2778
p.S196L	DO37819	SKCM	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation rewiring degron network	0.2778
p.L198I	TCGA-FU-A2QG	CESC	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation altering degron motif	0.6063
p.L198I	DO6253	CESC	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation altering degron motif	0.6063
p.V215M	TCGA-GS-A9TQ	DLBC	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation rewiring degron network	0.0556
p.V215M	DO219911	DLBC	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation rewiring degron network	0.0556
p.V215M	DO228604	PRAD	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation rewiring degron network	0.0556
p.C213R	TCGA-NC-A5HQ	LUSC	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation rewiring degron network	0.1111
p.C213R	DO219201	LUSC	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation rewiring degron network	0.1111
p.L211F	DO220913	MELA	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation rewiring degron network	0.1667
p.E205K	DO222546	MELA	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation altering degron motif	0.7022
p.R194C	DO232352	PBCA	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation rewiring degron network	0.2222
p.R194H	DO51047	PRAD	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	198:205	Mutation rewiring degron network	0.2222

Kaplan plot for SIGLEC14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SIGLEC14

UniProt ID: Q08ET2

Entrez ID: 100049587

Protein name: Sialic acid-binding Ig-like lectin 14 (Siglec-14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SIGLEC14 in