DegronMD

Uniprot ID: Q08ET2

Source protein: Sialic acid-binding Ig-like lectin 14

Source gene: SIGLEC14

Class: DEG_SCF_FBW7_2

Location: 198:205

E3 ligase: FBXW7

DEGRON score: 0.9431

ASA_SCORE: 51.0625

COIL: 0.3846

CONS_SCORE: 0.9062

DSS_SCORE: 0.684

HELIX: 0.2288

FCONS_SCORE: 1.3364

RIG_SCORE: 0.6643

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H207N	TCGA-44-3396	LUAD	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	0.2778
p.H207N	DO23559	LUAD	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	0.2778
p.P202H	TCGA-49-AAR4	LUAD	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	0.7694
p.P202H	DO218920	LUAD	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	0.7694
p.T209I	TCGA-56-A62T	LUSC	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	0.2222
p.T209I	DO219144	LUSC	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	0.2222
p.G208A	TCGA-66-2767	LUSC	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	0.25
p.G208A	DO26713	LUSC	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	0.25
p.P202T	TCGA-67-3770	LUAD	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	0.7031
p.P202T	DO23932	LUAD	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	0.7031
p.D206N	TCGA-DX-A8BP	SARC	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	0.3056
p.D206N	DO220056	SARC	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	0.3056
p.S196L	TCGA-EE-A2MR	SKCM	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	0.2778
p.S196L	DO37819	SKCM	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	0.2778
p.L198I	TCGA-FU-A2QG	CESC	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	0.6063
p.L198I	DO6253	CESC	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	0.6063
p.V215M	TCGA-GS-A9TQ	DLBC	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	0.0556
p.V215M	DO219911	DLBC	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	0.0556
p.V215M	DO228604	PRAD	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	0.0556
p.C213R	TCGA-NC-A5HQ	LUSC	TCGA	LTLTPRPE	DEG_SCF_FBW7_2	0.1111
p.C213R	DO219201	LUSC	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	0.1111
p.L211F	DO220913	MELA	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	0.1667
p.E205K	DO222546	MELA	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	0.7022
p.R194C	DO232352	PBCA	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	0.2222
p.R194H	DO51047	PRAD	ICGC	LTLTPRPE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08ET2	Sialic acid-binding Ig-like lectin 14	DEG_SCF_FBW7_2	198:205	LTLTPRPE	FBXW7	0.9431	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons