DegronMD - Q09013(DMPK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R358L	TCGA-44-7661	LUAD	TCGA	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation altering degron motif	0.8428
p.R358L	TCGA-CN-6010	HNSC	TCGA	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation altering degron motif	0.8428
p.E369K	TCGA-A5-A2K5	UCEC	TCGA	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.0556
p.D353N	TCGA-B5-A3FC	UCEC	TCGA	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation altering degron motif	0.6932
p.D353N	TCGA-FI-A2D5	UCEC	TCGA	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation altering degron motif	0.6932
p.D353N	DO41871	UCEC	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation altering degron motif	0.6932
p.D353N	DO41331	UCEC	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation altering degron motif	0.6932
p.D353N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation altering degron motif	0.6932
p.D353N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation altering degron motif	0.6932
p.V361M	TCGA-EC-A1QX	UCEC	TCGA	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.2778
p.D342N	TCGA-EO-A22U	UCEC	TCGA	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.0556
p.D342N	DO43755	UCEC	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.0556
p.G351S	TCGA-IB-7651	PAAD	TCGA	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.3056
p.G351S	DO46657	PAAD	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.3056
p.D343G	DO233258	GACA	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.0833
p.T364I	DO233709	GACA	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.1944
p.R348L	DO14766	HNSC	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.2222
p.R348L	DO23602	LUAD	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.2222
p.T362S	DO26922	LUSC	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.25
p.V351M	DO42592	UCEC	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.3056
p.E359K	DO41379	UCEC	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation altering degron motif	0.7022
p.D359N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation altering degron motif	0.6932
p.D359N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation altering degron motif	0.6932
p.P347R	SIDM00202	Ewing's Sarcoma	GDSC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.1944
p.P347R	SIDM00101	Mesothelioma	GDSC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.1944
p.S360N	SIDM00333	Endometrial Carcinoma	GDSC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.3056
p.S360N	MFE-319	endometrium	COSMIC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.3056
p.R344Q	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.1111
p.R344Q	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.1111
p.S350N	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.2778
p.S350N	MFE-319	endometrium	COSMIC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.2778
p.D343N	ACH-001127	Leukemia	CCLE	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.0833
p.D343N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.0833
p.D349N	ACH-002256	Leukemia	CCLE	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.25
p.D349N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPFTPDFE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.25

Kaplan plot for DMPK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DMPK

UniProt ID: Q09013

Entrez ID: 1760

Protein name: Myotonin-protein kinase (MT-PK) (EC 2.7.11.1) (DM-kinase) (DMK) (DM1 protein kinase) (DMPK) (Myotonic dystrophy protein kinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DMPK in