DegronMD

Uniprot ID: Q09013

Source protein: Myotonin-protein kinase

Source gene: DMPK

Class: DEG_SCF_FBW7_2

Location: 352:359

E3 ligase: FBXW7

DEGRON score: 0.9903

ASA_SCORE: 57.2

COIL: 0.8721

CONS_SCORE: 0.719

DSS_SCORE: 0.4451

HELIX: 0.0106

FCONS_SCORE: 1.0044

RIG_SCORE: 0.7745

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R358L	TCGA-44-7661	LUAD	TCGA	PPFTPDFE	DEG_SCF_FBW7_2	0.8428
p.R358L	TCGA-CN-6010	HNSC	TCGA	PPFTPDFE	DEG_SCF_FBW7_2	0.8428
p.E369K	TCGA-A5-A2K5	UCEC	TCGA	PPFTPDFE	DEG_SCF_FBW7_2	0.0556
p.D353N	TCGA-B5-A3FC	UCEC	TCGA	PPFTPDFE	DEG_SCF_FBW7_2	0.6932
p.D353N	TCGA-FI-A2D5	UCEC	TCGA	PPFTPDFE	DEG_SCF_FBW7_2	0.6932
p.D353N	DO41871	UCEC	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	0.6932
p.D353N	DO41331	UCEC	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	0.6932
p.D353N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPFTPDFE	DEG_SCF_FBW7_2	0.6932
p.D353N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PPFTPDFE	DEG_SCF_FBW7_2	0.6932
p.V361M	TCGA-EC-A1QX	UCEC	TCGA	PPFTPDFE	DEG_SCF_FBW7_2	0.2778
p.D342N	TCGA-EO-A22U	UCEC	TCGA	PPFTPDFE	DEG_SCF_FBW7_2	0.0556
p.D342N	DO43755	UCEC	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	0.0556
p.G351S	TCGA-IB-7651	PAAD	TCGA	PPFTPDFE	DEG_SCF_FBW7_2	0.3056
p.G351S	DO46657	PAAD	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	0.3056
p.D343G	DO233258	GACA	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	0.0833
p.T364I	DO233709	GACA	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	0.1944
p.R348L	DO14766	HNSC	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	0.2222
p.R348L	DO23602	LUAD	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	0.2222
p.T362S	DO26922	LUSC	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	0.25
p.V351M	DO42592	UCEC	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	0.3056
p.E359K	DO41379	UCEC	ICGC	PPFTPDFE	DEG_SCF_FBW7_2	0.7022
p.D359N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PPFTPDFE	DEG_SCF_FBW7_2	0.6932
p.D359N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PPFTPDFE	DEG_SCF_FBW7_2	0.6932
p.P347R	SIDM00202	Ewing's Sarcoma	GDSC	PPFTPDFE	DEG_SCF_FBW7_2	0.1944
p.P347R	SIDM00101	Mesothelioma	GDSC	PPFTPDFE	DEG_SCF_FBW7_2	0.1944
p.S360N	SIDM00333	Endometrial Carcinoma	GDSC	PPFTPDFE	DEG_SCF_FBW7_2	0.3056
p.S360N	MFE-319	endometrium	COSMIC	PPFTPDFE	DEG_SCF_FBW7_2	0.3056
p.R344Q	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PPFTPDFE	DEG_SCF_FBW7_2	0.1111
p.R344Q	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PPFTPDFE	DEG_SCF_FBW7_2	0.1111
p.S350N	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPFTPDFE	DEG_SCF_FBW7_2	0.2778
p.S350N	MFE-319	endometrium	COSMIC	PPFTPDFE	DEG_SCF_FBW7_2	0.2778
p.D343N	ACH-001127	Leukemia	CCLE	PPFTPDFE	DEG_SCF_FBW7_2	0.0833
p.D343N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PPFTPDFE	DEG_SCF_FBW7_2	0.0833
p.D349N	ACH-002256	Leukemia	CCLE	PPFTPDFE	DEG_SCF_FBW7_2	0.25
p.D349N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PPFTPDFE	DEG_SCF_FBW7_2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPFTPDFE

Degron related mutations and impact score

Drug responses associated with DMPK mutations

All proteins holding degron of PPFTPDFE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09013	Myotonin-protein kinase	DEG_SCF_FBW7_2	352:359	PPFTPDFE	FBXW7	0.9903	More...