DegronMD - Q09028(RBBP4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P158S	TCGA-AP-A1DK	UCEC	TCGA	DVLVFDYTKHP	CBL_PTK	148:158	Mutation altering degron motif	0.6752
p.I140V	TCGA-BR-8372	STAD	TCGA	DVLVFDYTKHP	CBL_PTK	148:158	Mutation rewiring degron network	0.1111
p.G140E	DO51948	BLCA	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation rewiring degron network	0.1111
p.D159H	DO49976	CESC	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation blocking phosphorylation signal	0.75
p.E154D	DO8264	COAD	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation altering degron motif	0.6758
p.V166M	DO233767	GACA	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation rewiring degron network	0.1111
p.V166M	DO229057	LICA	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation rewiring degron network	0.1111
p.D159N	DO52042	HNSC	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation blocking phosphorylation signal	0.75
p.N155I	DO52212	LIHC	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation altering degron motif	0.728
p.A153T	DO52212	LIHC	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation altering degron motif	0.7139
p.L159F	DO52278	LIHC	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation blocking phosphorylation signal	0.75
p.L154F	DO220891	MELA	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation altering degron motif	0.6981
p.LR138LC	DO222868	MELA	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation rewiring degron network	0
p.D163E	DO51526	PACA	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation rewiring degron network	0.1944
p.N153S	DO227558	PACA	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation altering degron motif	0.7069
p.G145V	DO220312	SARC	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation rewiring degron network	0.25
p.V149A	DO37559	SKCM	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation altering degron motif	0.5825
p.S140Y	DO47407	SKCM	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation rewiring degron network	0.1111
p.D164G	DO38815	STAD	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation rewiring degron network	0.1667
p.G147E	DO38659	STAD	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation blocking phosphorylation signal	0.75
p.G156V	DO47833	STAD	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation altering degron motif	0.7532
p.I146T	DO41572	UCEC	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation blocking phosphorylation signal	0.7222
p.L159I	DO42472	UCEC	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation blocking phosphorylation signal	0.75
p.S140F	DO41361	UCEC	ICGC	DVLVFDYTKHP	CBL_PTK	148:158	Mutation rewiring degron network	0.1111

Kaplan plot for RBBP4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBBP4

UniProt ID: Q09028

Entrez ID: 5928

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBBP4 in