DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DVLVFDYTKHP
Uniprot ID:
Q09028
Source protein:
Histone-binding protein RBBP4
Source gene:
RBBP4
Class:
CBL_PTK
Location:
148:158
E3 ligase:
CBL
DEGRON score:
0.9041
ASA_SCORE:
32.4364
COIL:
0.4746
CONS_SCORE:
0.5632
DSS_SCORE:
0.4947
HELIX:
0.018
FCONS_SCORE:
1.1972
RIG_SCORE:
0.7437
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P158S
TCGA-AP-A1DK
UCEC
TCGA
DVLVFDYTKHP
CBL_PTK
0.6752
p.I140V
TCGA-BR-8372
STAD
TCGA
DVLVFDYTKHP
CBL_PTK
0.1111
p.G140E
DO51948
BLCA
ICGC
DVLVFDYTKHP
CBL_PTK
0.1111
p.D159H
DO49976
CESC
ICGC
DVLVFDYTKHP
CBL_PTK
0.75
p.E154D
DO8264
COAD
ICGC
DVLVFDYTKHP
CBL_PTK
0.6758
p.V166M
DO233767
GACA
ICGC
DVLVFDYTKHP
CBL_PTK
0.1111
p.V166M
DO229057
LICA
ICGC
DVLVFDYTKHP
CBL_PTK
0.1111
p.D159N
DO52042
HNSC
ICGC
DVLVFDYTKHP
CBL_PTK
0.75
p.N155I
DO52212
LIHC
ICGC
DVLVFDYTKHP
CBL_PTK
0.728
p.A153T
DO52212
LIHC
ICGC
DVLVFDYTKHP
CBL_PTK
0.7139
p.L159F
DO52278
LIHC
ICGC
DVLVFDYTKHP
CBL_PTK
0.75
p.L154F
DO220891
MELA
ICGC
DVLVFDYTKHP
CBL_PTK
0.6981
p.LR138LC
DO222868
MELA
ICGC
DVLVFDYTKHP
CBL_PTK
0
p.D163E
DO51526
PACA
ICGC
DVLVFDYTKHP
CBL_PTK
0.1944
p.N153S
DO227558
PACA
ICGC
DVLVFDYTKHP
CBL_PTK
0.7069
p.G145V
DO220312
SARC
ICGC
DVLVFDYTKHP
CBL_PTK
0.25
p.V149A
DO37559
SKCM
ICGC
DVLVFDYTKHP
CBL_PTK
0.5825
p.S140Y
DO47407
SKCM
ICGC
DVLVFDYTKHP
CBL_PTK
0.1111
p.D164G
DO38815
STAD
ICGC
DVLVFDYTKHP
CBL_PTK
0.1667
p.G147E
DO38659
STAD
ICGC
DVLVFDYTKHP
CBL_PTK
0.75
p.G156V
DO47833
STAD
ICGC
DVLVFDYTKHP
CBL_PTK
0.7532
p.I146T
DO41572
UCEC
ICGC
DVLVFDYTKHP
CBL_PTK
0.7222
p.L159I
DO42472
UCEC
ICGC
DVLVFDYTKHP
CBL_PTK
0.75
p.S140F
DO41361
UCEC
ICGC
DVLVFDYTKHP
CBL_PTK
0.1111
Drug responses associated with RBBP4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DVLVFDYTKHP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q09028
Histone-binding protein RBBP4
CBL_PTK
148:158
DVLVFDYTKHP
CBL
0.9041
More...