DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DVLVFDYTKHP
Uniprot ID:
Q09028
Source protein:
Histone-binding protein RBBP4
Source gene:
RBBP4
Class:
CBL_PTK
Location:
148:158
E3 ligase:
CBL
DEGRON score:
0.9041
ASA_SCORE:
32.4364
COIL:
0.4746
CONS_SCORE:
0.5632
DSS_SCORE:
0.4947
HELIX:
0.018
FCONS_SCORE:
1.1972
RIG_SCORE:
0.7437
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G156V
DO47833
STAD
ICGC
DVLVFDYTKHP
CBL_PTK
0.7532
p.D159H
DO49976
CESC
ICGC
DVLVFDYTKHP
CBL_PTK
0.75
p.D159N
DO52042
HNSC
ICGC
DVLVFDYTKHP
CBL_PTK
0.75
p.L159F
DO52278
LIHC
ICGC
DVLVFDYTKHP
CBL_PTK
0.75
p.G147E
DO38659
STAD
ICGC
DVLVFDYTKHP
CBL_PTK
0.75
p.L159I
DO42472
UCEC
ICGC
DVLVFDYTKHP
CBL_PTK
0.75
p.N155I
DO52212
LIHC
ICGC
DVLVFDYTKHP
CBL_PTK
0.728
p.I146T
DO41572
UCEC
ICGC
DVLVFDYTKHP
CBL_PTK
0.7222
p.A153T
DO52212
LIHC
ICGC
DVLVFDYTKHP
CBL_PTK
0.7139
p.N153S
DO227558
PACA
ICGC
DVLVFDYTKHP
CBL_PTK
0.7069
p.L154F
DO220891
MELA
ICGC
DVLVFDYTKHP
CBL_PTK
0.6981
p.E154D
DO8264
COAD
ICGC
DVLVFDYTKHP
CBL_PTK
0.6758
p.P158S
TCGA-AP-A1DK
UCEC
TCGA
DVLVFDYTKHP
CBL_PTK
0.6752
p.V149A
DO37559
SKCM
ICGC
DVLVFDYTKHP
CBL_PTK
0.5825
p.G145V
DO220312
SARC
ICGC
DVLVFDYTKHP
CBL_PTK
0.25
p.D163E
DO51526
PACA
ICGC
DVLVFDYTKHP
CBL_PTK
0.1944
p.D164G
DO38815
STAD
ICGC
DVLVFDYTKHP
CBL_PTK
0.1667
p.I140V
TCGA-BR-8372
STAD
TCGA
DVLVFDYTKHP
CBL_PTK
0.1111
p.G140E
DO51948
BLCA
ICGC
DVLVFDYTKHP
CBL_PTK
0.1111
p.V166M
DO233767
GACA
ICGC
DVLVFDYTKHP
CBL_PTK
0.1111
p.V166M
DO229057
LICA
ICGC
DVLVFDYTKHP
CBL_PTK
0.1111
p.S140Y
DO47407
SKCM
ICGC
DVLVFDYTKHP
CBL_PTK
0.1111
p.S140F
DO41361
UCEC
ICGC
DVLVFDYTKHP
CBL_PTK
0.1111
p.LR138LC
DO222868
MELA
ICGC
DVLVFDYTKHP
CBL_PTK
0
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Drug responses associated with RBBP4 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of DVLVFDYTKHP
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q09028
Histone-binding protein RBBP4
CBL_PTK
148:158
DVLVFDYTKHP
CBL
0.9041
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