DegronMD - Q09328(MGAT5)

FUNCTION: Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides (PubMed:10395745, PubMed:30140003). Catalyzes an important step in the biosynthesis of branched, complex-type N-glycans, such as those found on EGFR, TGFR (TGF-beta receptor) and CDH2 (PubMed:10395745, PubMed:22614033, PubMed:30140003). Via its role in the biosynthesis of complex N-glycans, plays an important role in the activation of cellular signaling pathways, reorganization of the actin cytoskeleton, cell-cell adhesion and cell migration. MGAT5-dependent EGFR N-glycosylation enhances the interaction between EGFR and LGALS3 and thereby prevents rapid EGFR endocytosis and prolongs EGFR signaling. Required for efficient interaction between TGFB1 and its receptor. Enhances activation of intracellular signaling pathways by several types of growth factors, including FGF2, PDGF, IGF, TGFB1 and EGF. MGAT5-dependent CDH2 N-glycosylation inhibits CDH2-mediated homotypic cell-cell adhesion and contributes to the regulation of downstream signaling pathways. Promotes cell migration. Contributes to the regulation of the inflammatory response. MGAT5-dependent TCR N-glycosylation enhances the interaction between TCR and LGALS3, limits agonist-induced TCR clustering, and thereby dampens TCR-mediated responses to antigens. Required for normal leukocyte evasation and accumulation at sites of inflammation (By similarity). Inhibits attachment of monocytes to the vascular endothelium and subsequent monocyte diapedesis (PubMed:22614033). {ECO:0000250|UniProtKB:Q8R4G6, ECO:0000269|PubMed:10395745, ECO:0000269|PubMed:22614033, ECO:0000269|PubMed:30140003}.; FUNCTION: [Secreted alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A]: Promotes proliferation of umbilical vein endothelial cells and angiogenesis, at least in part by promoting the release of the growth factor FGF2 from the extracellular matrix. {ECO:0000269|PubMed:11872751}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A135E	TCGA-DI-A1BU	UCEC	TCGA	STNSTTAVPSL	DEG_COP1_1	116:126	Mutation rewiring degron network	0.0833
p.A135E	DO42023	UCEC	ICGC	STNSTTAVPSL	DEG_COP1_1	116:126	Mutation rewiring degron network	0.0833
p.S119C	TCGA-EK-A2RJ	CESC	TCGA	STNSTTAVPSL	DEG_COP1_1	116:126	Mutation altering degron motif	0.643
p.S119C	DO49950	CESC	ICGC	STNSTTAVPSL	DEG_COP1_1	116:126	Mutation altering degron motif	0.643
p.G113R	DO233737	GACA	ICGC	STNSTTAVPSL	DEG_COP1_1	116:126	Mutation rewiring degron network	0.25
p.G111D	DO233871	GACA	ICGC	STNSTTAVPSL	DEG_COP1_1	116:126	Mutation rewiring degron network	0.1944
p.G111V	DO229035	LICA	ICGC	STNSTTAVPSL	DEG_COP1_1	116:126	Mutation rewiring degron network	0.1944
p.V123I	DO229008	LICA	ICGC	STNSTTAVPSL	DEG_COP1_1	116:126	Mutation altering degron motif	0.7076
p.S119P	DO222837	MELA	ICGC	STNSTTAVPSL	DEG_COP1_1	116:126	Mutation altering degron motif	0.5641
p.L126F	SIDM00524	Small Cell Lung Carcinoma	GDSC	STNSTTAVPSL	DEG_COP1_1	116:126	Mutation altering degron motif	0.587
p.L126F	ACH-000703	Lung Cancer	CCLE	STNSTTAVPSL	DEG_COP1_1	116:126	Mutation altering degron motif	0.587
p.L126F	DMS-79	lung	COSMIC	STNSTTAVPSL	DEG_COP1_1	116:126	Mutation altering degron motif	0.587
p.V123F	SIDM00615	Hepatocellular Carcinoma	GDSC	STNSTTAVPSL	DEG_COP1_1	116:126	Mutation altering degron motif	0.7068
p.V123F	ACH-000217	Liver Cancer	CCLE	STNSTTAVPSL	DEG_COP1_1	116:126	Mutation altering degron motif	0.7068
p.V123F	JHH-6	liver	COSMIC	STNSTTAVPSL	DEG_COP1_1	116:126	Mutation altering degron motif	0.7068

Kaplan plot for MGAT5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MGAT5

UniProt ID: Q09328

Entrez ID: 4249

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MGAT5 in