DegronMD

Uniprot ID: Q09328

Source protein: Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

Source gene: MGAT5

Class: DEG_COP1_1

Location: 116:126

E3 ligase: COP1

DEGRON score: 0.6375

ASA_SCORE: 75.4091

COIL: 0.841

CONS_SCORE: 0.3879

DSS_SCORE: 0.3444

HELIX: 0.0905

FCONS_SCORE: 0.9961

RIG_SCORE: 0.7814

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A135E	TCGA-DI-A1BU	UCEC	TCGA	STNSTTAVPSL	DEG_COP1_1	0.0833
p.A135E	DO42023	UCEC	ICGC	STNSTTAVPSL	DEG_COP1_1	0.0833
p.S119C	TCGA-EK-A2RJ	CESC	TCGA	STNSTTAVPSL	DEG_COP1_1	0.643
p.S119C	DO49950	CESC	ICGC	STNSTTAVPSL	DEG_COP1_1	0.643
p.G113R	DO233737	GACA	ICGC	STNSTTAVPSL	DEG_COP1_1	0.25
p.G111D	DO233871	GACA	ICGC	STNSTTAVPSL	DEG_COP1_1	0.1944
p.G111V	DO229035	LICA	ICGC	STNSTTAVPSL	DEG_COP1_1	0.1944
p.V123I	DO229008	LICA	ICGC	STNSTTAVPSL	DEG_COP1_1	0.7076
p.S119P	DO222837	MELA	ICGC	STNSTTAVPSL	DEG_COP1_1	0.5641
p.L126F	SIDM00524	Small Cell Lung Carcinoma	GDSC	STNSTTAVPSL	DEG_COP1_1	0.587
p.L126F	ACH-000703	Lung Cancer	CCLE	STNSTTAVPSL	DEG_COP1_1	0.587
p.L126F	DMS-79	lung	COSMIC	STNSTTAVPSL	DEG_COP1_1	0.587
p.V123F	SIDM00615	Hepatocellular Carcinoma	GDSC	STNSTTAVPSL	DEG_COP1_1	0.7068
p.V123F	ACH-000217	Liver Cancer	CCLE	STNSTTAVPSL	DEG_COP1_1	0.7068
p.V123F	JHH-6	liver	COSMIC	STNSTTAVPSL	DEG_COP1_1	0.7068

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09328	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A	DEG_COP1_1	116:126	STNSTTAVPSL	COP1	0.6375	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons