DegronMD - Q0P6D6(CCDC15)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K194N	TCGA-EE-A181	SKCM	TCGA	KGSVFPD	LIG_APCC_ABBAyCdc20_2	194:200	Mutation altering degron motif	0.6918
p.K194N	DO37444	SKCM	ICGC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	194:200	Mutation altering degron motif	0.6918
p.K194R	TCGA-F1-6874	STAD	TCGA	KGSVFPD	LIG_APCC_ABBAyCdc20_2	194:200	Mutation altering degron motif	0.6126
p.K194R	DO38201	STAD	ICGC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	194:200	Mutation altering degron motif	0.6126
p.K194R	SIDM01608	Endometrial Carcinoma	GDSC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	194:200	Mutation altering degron motif	0.6126
p.K194R	ACH-000990	Endometrial/Uterine Cancer	CCLE	KGSVFPD	LIG_APCC_ABBAyCdc20_2	194:200	Mutation altering degron motif	0.6126
p.L207F	TCGA-GN-A4U7	SKCM	TCGA	KGSVFPD	LIG_APCC_ABBAyCdc20_2	194:200	Mutation rewiring degron network	0.1389
p.L207F	DO51258	SKCM	ICGC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	194:200	Mutation rewiring degron network	0.1389
p.R209T	TCGA-K4-A5RJ	BLCA	TCGA	KGSVFPD	LIG_APCC_ABBAyCdc20_2	194:200	Mutation rewiring degron network	0.0833
p.R209T	DO49784	BLCA	ICGC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	194:200	Mutation rewiring degron network	0.0833
p.R209T	DO26475	LUSC	ICGC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	194:200	Mutation rewiring degron network	0.0833
p.R203K	TCGA-LN-A9FP	ESCA	TCGA	KGSVFPD	LIG_APCC_ABBAyCdc20_2	194:200	Mutation rewiring degron network	0.25
p.G195A	DO46330	OV	ICGC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	194:200	Mutation altering degron motif	0.6429
p.K204E	SIDM00317	Kidney Carcinoma	GDSC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	194:200	Mutation substituting flanking lysine	0.3333
p.K204E	ACH-000171	Kidney Cancer	CCLE	KGSVFPD	LIG_APCC_ABBAyCdc20_2	194:200	Mutation substituting flanking lysine	0.3333
p.K204E	VMRC-RCZ	kidney	COSMIC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	194:200	Mutation substituting flanking lysine	0.3333
p.S186P	SIDM00493	Other Solid Cancers	GDSC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	194:200	Mutation blocking phosphorylation signal	0.5556

Kaplan plot for CCDC15 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC15

UniProt ID: Q0P6D6

Entrez ID: 80071

Protein name: Coiled-coil domain-containing protein 15

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC15 in