DegronMD

Uniprot ID: Q0P6D6

Source protein: Coiled-coil domain-containing protein 15

Source gene: CCDC15

Class: LIG_APCC_ABBAyCdc20_2

Location: 194:200

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9923

ASA_SCORE: 94.4286

COIL: 0.9096

CONS_SCORE: 0.932

DSS_SCORE: 0.3551

HELIX: 0.0394

FCONS_SCORE: 1.0075

RIG_SCORE: 0.7198

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K194N	TCGA-EE-A181	SKCM	TCGA	KGSVFPD	LIG_APCC_ABBAyCdc20_2	0.6918
p.K194N	DO37444	SKCM	ICGC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	0.6918
p.K194R	TCGA-F1-6874	STAD	TCGA	KGSVFPD	LIG_APCC_ABBAyCdc20_2	0.6126
p.K194R	DO38201	STAD	ICGC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	0.6126
p.K194R	SIDM01608	Endometrial Carcinoma	GDSC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	0.6126
p.K194R	ACH-000990	Endometrial/Uterine Cancer	CCLE	KGSVFPD	LIG_APCC_ABBAyCdc20_2	0.6126
p.L207F	TCGA-GN-A4U7	SKCM	TCGA	KGSVFPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.L207F	DO51258	SKCM	ICGC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R209T	TCGA-K4-A5RJ	BLCA	TCGA	KGSVFPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R209T	DO49784	BLCA	ICGC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R209T	DO26475	LUSC	ICGC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R203K	TCGA-LN-A9FP	ESCA	TCGA	KGSVFPD	LIG_APCC_ABBAyCdc20_2	0.25
p.G195A	DO46330	OV	ICGC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	0.6429
p.K204E	SIDM00317	Kidney Carcinoma	GDSC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	0.3333
p.K204E	ACH-000171	Kidney Cancer	CCLE	KGSVFPD	LIG_APCC_ABBAyCdc20_2	0.3333
p.K204E	VMRC-RCZ	kidney	COSMIC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	0.3333
p.S186P	SIDM00493	Other Solid Cancers	GDSC	KGSVFPD	LIG_APCC_ABBAyCdc20_2	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0P6D6	Coiled-coil domain-containing protein 15	LIG_APCC_ABBAyCdc20_2	194:200	KGSVFPD	APC,CDC20,FZR1	0.9923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons