DegronMD - Q0VD86(INCA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R112W	TCGA-BR-8368	STAD	TCGA	RRPCLEGMQ	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.0556
p.R112W	DO47981	STAD	ICGC	RRPCLEGMQ	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.0556
p.R112W	SIDM00492	Glioblastoma	GDSC	RRPCLEGMQ	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.0556
p.R112W	SIDM01735	Biliary Tract Carcinoma	GDSC	RRPCLEGMQ	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.0556
p.R112Q	TCGA-CG-4460	STAD	TCGA	RRPCLEGMQ	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.0556
p.R112Q	DO38427	STAD	ICGC	RRPCLEGMQ	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.0556
p.G100E	TCGA-Z2-A8RT	SKCM	TCGA	RRPCLEGMQ	DEG_APCC_DBOX_1	94:102	Mutation altering degron motif	0.6087
p.AR96AW	DO222880	MELA	ICGC	RRPCLEGMQ	DEG_APCC_DBOX_1	94:102	Mutation altering degron motif	0.6952
p.G85E	DO51301	SKCM	ICGC	RRPCLEGMQ	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.0833
p.P96S	SIDM01278	Colorectal Carcinoma	GDSC	RRPCLEGMQ	DEG_APCC_DBOX_1	94:102	Mutation altering degron motif	0.5641
p.W89C	SIDM00938	Breast Carcinoma	GDSC	RRPCLEGMQ	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.1944
p.W89C	ACH-000902	Breast Cancer	CCLE	RRPCLEGMQ	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.1944
p.W89C	CAL-148	breast	COSMIC	RRPCLEGMQ	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.1944
p.H104N	SNU-1040	large intestine	COSMIC	RRPCLEGMQ	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons