DegronMD

Uniprot ID: Q0VD86

Source protein: Protein INCA1

Source gene: INCA1

Class: DEG_APCC_DBOX_1

Location: 94:102

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.555

ASA_SCORE: 101.3111

COIL: 0.7189

CONS_SCORE: 0.5628

DSS_SCORE: 0.517

HELIX: 0.2291

FCONS_SCORE: 0.7334

RIG_SCORE: 0.735

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R112W	TCGA-BR-8368	STAD	TCGA	RRPCLEGMQ	DEG_APCC_DBOX_1	0.0556
p.R112W	DO47981	STAD	ICGC	RRPCLEGMQ	DEG_APCC_DBOX_1	0.0556
p.R112W	SIDM00492	Glioblastoma	GDSC	RRPCLEGMQ	DEG_APCC_DBOX_1	0.0556
p.R112W	SIDM01735	Biliary Tract Carcinoma	GDSC	RRPCLEGMQ	DEG_APCC_DBOX_1	0.0556
p.R112Q	TCGA-CG-4460	STAD	TCGA	RRPCLEGMQ	DEG_APCC_DBOX_1	0.0556
p.R112Q	DO38427	STAD	ICGC	RRPCLEGMQ	DEG_APCC_DBOX_1	0.0556
p.G100E	TCGA-Z2-A8RT	SKCM	TCGA	RRPCLEGMQ	DEG_APCC_DBOX_1	0.6087
p.AR96AW	DO222880	MELA	ICGC	RRPCLEGMQ	DEG_APCC_DBOX_1	0.6952
p.G85E	DO51301	SKCM	ICGC	RRPCLEGMQ	DEG_APCC_DBOX_1	0.0833
p.P96S	SIDM01278	Colorectal Carcinoma	GDSC	RRPCLEGMQ	DEG_APCC_DBOX_1	0.5641
p.W89C	SIDM00938	Breast Carcinoma	GDSC	RRPCLEGMQ	DEG_APCC_DBOX_1	0.1944
p.W89C	ACH-000902	Breast Cancer	CCLE	RRPCLEGMQ	DEG_APCC_DBOX_1	0.1944
p.W89C	CAL-148	breast	COSMIC	RRPCLEGMQ	DEG_APCC_DBOX_1	0.1944
p.H104N	SNU-1040	large_intestine	COSMIC	RRPCLEGMQ	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0VD86	Protein INCA1	DEG_APCC_DBOX_1	94:102	RRPCLEGMQ	APC,CDC20,FZR1	0.555	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons