DegronMD - Q0VFZ6(CFAP210)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A521T	TCGA-63-A5MB	LUSC	TCGA	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation rewiring degron network	0.0556
p.A521T	DO52018	LUSC	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation rewiring degron network	0.0556
p.G506A	TCGA-AC-A5XS	BRCA	TCGA	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation altering degron motif	0.6429
p.G506A	DO50023	BRCA	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation altering degron motif	0.6429
p.A521V	TCGA-B5-A3FA	UCEC	TCGA	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation rewiring degron network	0.0556
p.A521V	DO52402	UCEC	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation rewiring degron network	0.0556
p.G506E	TCGA-BF-AAP4	SKCM	TCGA	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation altering degron motif	0.6087
p.G506E	DO219468	SKCM	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation altering degron motif	0.6087
p.R512I	TCGA-EO-A22R	UCEC	TCGA	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation rewiring degron network	0.3056
p.R512I	DO42713	UCEC	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation rewiring degron network	0.3056
p.G514E	TCGA-WE-A8K5	SKCM	TCGA	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation rewiring degron network	0.25
p.G514E	DO51282	SKCM	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation rewiring degron network	0.25
p.R512T	TCGA-ZF-AA51	BLCA	TCGA	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation rewiring degron network	0.3056
p.R512T	DO219093	BLCA	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation rewiring degron network	0.3056
p.D511N	DO50337	ESAD	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation altering degron motif	0.6932
p.P501H	DO229037	LICA	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation rewiring degron network	0.2222
p.Q520E	DO221545	PACA	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation rewiring degron network	0.0833
p.P501S	SIDM00672	Hepatocellular Carcinoma	GDSC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation rewiring degron network	0.2222
p.P501S	SIDM00694	Other Solid Cancers	GDSC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation rewiring degron network	0.2222
p.P501S	SIDM00878	Breast Carcinoma	GDSC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation rewiring degron network	0.2222
p.P501S	SIDM00493	Other Solid Cancers	GDSC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation rewiring degron network	0.2222
p.P501S	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	505:511	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CFAP210

UniProt ID: Q0VFZ6

Entrez ID: 129881

Protein name: Protein CFAP210 (Cilia- and flagella- associated protein 210) (Coiled-coil domain-containing protein 173)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CFAP210 in