DegronMD

Uniprot ID: Q0VFZ6

Source protein: Protein CFAP210

Source gene: CFAP210

Class: LIG_APCC_ABBAyCdc20_2

Location: 505:511

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9908

ASA_SCORE: 72.6

COIL: 0.7129

CONS_SCORE: 0.402

DSS_SCORE: 0.5305

HELIX: 0.0344

FCONS_SCORE: 0.8256

RIG_SCORE: 0.7466

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A521T	TCGA-63-A5MB	LUSC	TCGA	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A521T	DO52018	LUSC	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.0556
p.G506A	TCGA-AC-A5XS	BRCA	TCGA	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.6429
p.G506A	DO50023	BRCA	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.6429
p.A521V	TCGA-B5-A3FA	UCEC	TCGA	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A521V	DO52402	UCEC	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.0556
p.G506E	TCGA-BF-AAP4	SKCM	TCGA	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.6087
p.G506E	DO219468	SKCM	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.6087
p.R512I	TCGA-EO-A22R	UCEC	TCGA	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R512I	DO42713	UCEC	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G514E	TCGA-WE-A8K5	SKCM	TCGA	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.25
p.G514E	DO51282	SKCM	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.25
p.R512T	TCGA-ZF-AA51	BLCA	TCGA	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R512T	DO219093	BLCA	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D511N	DO50337	ESAD	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.6932
p.P501H	DO229037	LICA	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.Q520E	DO221545	PACA	ICGC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.0833
p.P501S	SIDM00672	Hepatocellular Carcinoma	GDSC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P501S	SIDM00694	Other Solid Cancers	GDSC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P501S	SIDM00878	Breast Carcinoma	GDSC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P501S	SIDM00493	Other Solid Cancers	GDSC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P501S	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	RGPVFVD	LIG_APCC_ABBAyCdc20_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0VFZ6	Protein CFAP210	LIG_APCC_ABBAyCdc20_2	505:511	RGPVFVD	APC,CDC20,FZR1	0.9908	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons