DegronMD - Q10570(CPSF1)

CPSF1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V740G	TCGA-04-1342	OV	TCGA	DSGSLFS	DEG_SCF_TRCP1_1	750:756	Mutation rewiring degron network	0.0556
p.V740G	DO29548	OV	ICGC	DSGSLFS	DEG_SCF_TRCP1_1	750:756	Mutation rewiring degron network	0.0556
p.S751L	TCGA-49-6767	LUAD	TCGA	DSGSLFS	DEG_SCF_TRCP1_1	750:756	Mutation altering degron motif	0.7667
p.S751L	DO23586	LUAD	ICGC	DSGSLFS	DEG_SCF_TRCP1_1	750:756	Mutation altering degron motif	0.7667
p.D742N	TCGA-EK-A2RM	CESC	TCGA	DSGSLFS	DEG_SCF_TRCP1_1	750:756	Mutation rewiring degron network	0.1111
p.D742N	DO49956	CESC	ICGC	DSGSLFS	DEG_SCF_TRCP1_1	750:756	Mutation rewiring degron network	0.1111
p.S753F	TCGA-EK-A3GK	CESC	TCGA	DSGSLFS	DEG_SCF_TRCP1_1	750:756	Mutation altering degron motif	0.7982
p.S753F	DO49964	CESC	ICGC	DSGSLFS	DEG_SCF_TRCP1_1	750:756	Mutation altering degron motif	0.7982
p.K759N	TCGA-FS-A1ZJ	SKCM	TCGA	DSGSLFS	DEG_SCF_TRCP1_1	750:756	Mutation blocking ubiquitination signal	0.6944
p.K759N	DO37956	SKCM	ICGC	DSGSLFS	DEG_SCF_TRCP1_1	750:756	Mutation blocking ubiquitination signal	0.6944
p.E743K	DO234239	ESAD	ICGC	DSGSLFS	DEG_SCF_TRCP1_1	750:756	Mutation rewiring degron network	0.1389
p.E743K	DO41217	UCEC	ICGC	DSGSLFS	DEG_SCF_TRCP1_1	750:756	Mutation rewiring degron network	0.1389
p.R764S	DO229489	LAML	ICGC	DSGSLFS	DEG_SCF_TRCP1_1	750:756	Mutation rewiring degron network	0.1111
p.L754F	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGSLFS	DEG_SCF_TRCP1_1	750:756	Mutation altering degron motif	0.587

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*NOTE: the Kaplan plots were collected from OncoLnc