DegronMD

Uniprot ID: Q10570

Source protein: Cleavage and polyadenylation specificity factor subunit 1

Source gene: CPSF1

Class: DEG_SCF_TRCP1_1

Location: 750:756

E3 ligase: BTRC

DEGRON score: 0.9268

ASA_SCORE: 58.7143

COIL: 0.7296

CONS_SCORE: 0.2627

DSS_SCORE: 0.6989

HELIX: 0.1489

FCONS_SCORE: 0.9705

RIG_SCORE: 0.6255

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S753F	TCGA-EK-A3GK	CESC	TCGA	DSGSLFS	DEG_SCF_TRCP1_1	0.7982
p.S753F	DO49964	CESC	ICGC	DSGSLFS	DEG_SCF_TRCP1_1	0.7982
p.S751L	TCGA-49-6767	LUAD	TCGA	DSGSLFS	DEG_SCF_TRCP1_1	0.7667
p.S751L	DO23586	LUAD	ICGC	DSGSLFS	DEG_SCF_TRCP1_1	0.7667
p.K759N	TCGA-FS-A1ZJ	SKCM	TCGA	DSGSLFS	DEG_SCF_TRCP1_1	0.6944
p.K759N	DO37956	SKCM	ICGC	DSGSLFS	DEG_SCF_TRCP1_1	0.6944
p.L754F	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGSLFS	DEG_SCF_TRCP1_1	0.587
p.E743K	DO234239	ESAD	ICGC	DSGSLFS	DEG_SCF_TRCP1_1	0.1389
p.E743K	DO41217	UCEC	ICGC	DSGSLFS	DEG_SCF_TRCP1_1	0.1389
p.D742N	TCGA-EK-A2RM	CESC	TCGA	DSGSLFS	DEG_SCF_TRCP1_1	0.1111
p.D742N	DO49956	CESC	ICGC	DSGSLFS	DEG_SCF_TRCP1_1	0.1111
p.R764S	DO229489	LAML	ICGC	DSGSLFS	DEG_SCF_TRCP1_1	0.1111
p.V740G	TCGA-04-1342	OV	TCGA	DSGSLFS	DEG_SCF_TRCP1_1	0.0556
p.V740G	DO29548	OV	ICGC	DSGSLFS	DEG_SCF_TRCP1_1	0.0556

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q10570	Cleavage and polyadenylation specificity factor subunit 1	DEG_SCF_TRCP1_1	750:756	DSGSLFS	BTRC	0.9268	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons