DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSGSLFS
Uniprot ID:
Q10570
Source protein:
Cleavage and polyadenylation specificity factor subunit 1
Source gene:
CPSF1
Class:
DEG_SCF_TRCP1_1
Location:
750:756
E3 ligase:
BTRC
DEGRON score:
0.9268
ASA_SCORE:
58.7143
COIL:
0.7296
CONS_SCORE:
0.2627
DSS_SCORE:
0.6989
HELIX:
0.1489
FCONS_SCORE:
0.9705
RIG_SCORE:
0.6255
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V740G
TCGA-04-1342
OV
TCGA
DSGSLFS
DEG_SCF_TRCP1_1
0.0556
p.V740G
DO29548
OV
ICGC
DSGSLFS
DEG_SCF_TRCP1_1
0.0556
p.S751L
TCGA-49-6767
LUAD
TCGA
DSGSLFS
DEG_SCF_TRCP1_1
0.7667
p.S751L
DO23586
LUAD
ICGC
DSGSLFS
DEG_SCF_TRCP1_1
0.7667
p.D742N
TCGA-EK-A2RM
CESC
TCGA
DSGSLFS
DEG_SCF_TRCP1_1
0.1111
p.D742N
DO49956
CESC
ICGC
DSGSLFS
DEG_SCF_TRCP1_1
0.1111
p.S753F
TCGA-EK-A3GK
CESC
TCGA
DSGSLFS
DEG_SCF_TRCP1_1
0.7982
p.S753F
DO49964
CESC
ICGC
DSGSLFS
DEG_SCF_TRCP1_1
0.7982
p.K759N
TCGA-FS-A1ZJ
SKCM
TCGA
DSGSLFS
DEG_SCF_TRCP1_1
0.6944
p.K759N
DO37956
SKCM
ICGC
DSGSLFS
DEG_SCF_TRCP1_1
0.6944
p.E743K
DO234239
ESAD
ICGC
DSGSLFS
DEG_SCF_TRCP1_1
0.1389
p.E743K
DO41217
UCEC
ICGC
DSGSLFS
DEG_SCF_TRCP1_1
0.1389
p.R764S
DO229489
LAML
ICGC
DSGSLFS
DEG_SCF_TRCP1_1
0.1111
p.L754F
SIDM00412
B-Cell Non-Hodgkin's Lymphoma
GDSC
DSGSLFS
DEG_SCF_TRCP1_1
0.587
Drug responses associated with CPSF1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGSLFS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q10570
Cleavage and polyadenylation specificity factor subunit 1
DEG_SCF_TRCP1_1
750:756
DSGSLFS
BTRC
0.9268
More...