FUNCTION: Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligod...
FUNCTION: Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity). {ECO:0000250}.
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GO - Biological processes (BP):
axon guidance [GO:0007411]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; central nervous system myelin formation [GO:0032289]; cerebellum development [GO:0021549]; locomotory behavior [GO:0007626]; Notch signaling pathway [GO:0007219]; positive regulat...
axon guidance [GO:0007411]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; central nervous system myelin formation [GO:0032289]; cerebellum development [GO:0021549]; locomotory behavior [GO:0007626]; Notch signaling pathway [GO:0007219]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of sodium ion transport [GO:0010765]
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GO - Molecular function (MF):
carbohydrate binding [GO:0030246]; cell-cell adhesion mediator activity [GO:0098632]...
carbohydrate binding [GO:0030246]; cell-cell adhesion mediator activity [GO:0098632]
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GO - Cellular component (CC):
anchored component of postsynaptic membrane [GO:0099025]; anchored component of presynaptic membrane [GO:0099026]; axon [GO:0030424]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]...
anchored component of postsynaptic membrane [GO:0099025]; anchored component of presynaptic membrane [GO:0099026]; axon [GO:0030424]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]
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