DegronMD

Uniprot ID: Q12860

Source protein: Contactin-1

Source gene: CNTN1

Class: LIG_APCC_ABBA_1

Location: 1012:1017

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7645

ASA_SCORE: 71.1333

COIL: 0.241

CONS_SCORE: 0.2834

DSS_SCORE: 0.0627

HELIX: 0.0122

FCONS_SCORE: 0.8312

RIG_SCORE: 0.9579

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1011A	TCGA-49-AARE	LUAD	TCGA	ILVYLE	LIG_APCC_ABBA_1	0.3056
p.G1004C	TCGA-D3-A2JC	SKCM	TCGA	ILVYLE	LIG_APCC_ABBA_1	0.1111
p.E1017K	TCGA-EE-A3AG	SKCM	TCGA	ILVYLE	LIG_APCC_ABBA_1	0.7022
p.E1017K	DO37471	SKCM	ICGC	ILVYLE	LIG_APCC_ABBA_1	0.7022
p.F1018L	TCGA-OR-A5KB	ACC	TCGA	ILVYLE	LIG_APCC_ABBA_1	0.3056
p.F1018L	SIDM01611	Endometrial Carcinoma	GDSC	ILVYLE	LIG_APCC_ABBA_1	0.3056
p.F1018L	ACH-000996	Endometrial/Uterine Cancer	CCLE	ILVYLE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12860	Contactin-1	LIG_APCC_ABBA_1	1012:1017	ILVYLE	APC,CDC20,FZR1	0.7645	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons