DegronMD - Q12882(DPYD)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L461I	TCGA-06-5416	GBM	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation altering degron motif	0.7174
p.L461I	TCGA-AA-3510	COAD	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation altering degron motif	0.7174
p.L461I	DO7783	COAD	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation altering degron motif	0.7174
p.L461I	DO10880	GBM	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation altering degron motif	0.7174
p.L461I	DO232761	PBCA	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation altering degron motif	0.7174
p.R458K	TCGA-18-3409	LUSC	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation altering degron motif	0.7237
p.R458K	TCGA-DD-AADO	LIHC	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation altering degron motif	0.7237
p.R458K	DO52241	LIHC	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation altering degron motif	0.7237
p.R458K	DO26444	LUSC	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation altering degron motif	0.7237
p.N457Y	TCGA-50-5946	LUAD	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation altering degron motif	0.5948
p.N457Y	DO24556	LUAD	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation altering degron motif	0.5948
p.I454V	TCGA-60-2703	LUSC	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.25
p.I454V	DO27715	LUSC	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.25
p.Q470H	TCGA-A5-A0G1	UCEC	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.1944
p.Q470H	DO42472	UCEC	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.1944
p.V447L	TCGA-AZ-6601	COAD	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.0556
p.V447L	DO8119	COAD	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.0556
p.T471S	TCGA-CR-7371	HNSC	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.1667
p.T471S	DO15454	HNSC	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.1667
p.P466L	TCGA-D3-A8GP	SKCM	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.3056
p.P466L	DO51244	SKCM	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.3056
p.P462Q	TCGA-G7-6797	KIRP	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation altering degron motif	0.5924
p.P462Q	DO20917	KIRP	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation altering degron motif	0.5924
p.E473K	DO229456	SKCA	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.1111
p.E473K	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.1111
p.E473K	ACH-000562	Lung Cancer	CCLE	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.1111
p.E473K	HCC-78	lung	COSMIC	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.1111
p.L451F	SIDM00955	Melanoma	GDSC	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.1667
p.L451F	ACH-000812	Skin Cancer	CCLE	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.1667
p.L451F	COLO-783	skin	COSMIC	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.1667
p.A450V	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	NRWGLPEVD	DEG_APCC_DBOX_1	457:465	Mutation rewiring degron network	0.1389

Kaplan plot for DPYD in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DPYD

UniProt ID: Q12882

Entrez ID: 1806

Protein name: Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DPYD in