DegronMD

Uniprot ID: Q12882

Source protein: Dihydropyrimidine dehydrogenase [NADP

Source gene: DPYD

Class: DEG_APCC_DBOX_1

Location: 457:465

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8315

ASA_SCORE: 55.7111

COIL: 0.6811

CONS_SCORE: 0.4368

DSS_SCORE: 0.3567

HELIX: 0.0147

FCONS_SCORE: 1.1111

RIG_SCORE: 0.8012

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L461I	TCGA-06-5416	GBM	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	0.7174
p.L461I	TCGA-AA-3510	COAD	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	0.7174
p.L461I	DO7783	COAD	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	0.7174
p.L461I	DO10880	GBM	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	0.7174
p.L461I	DO232761	PBCA	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	0.7174
p.R458K	TCGA-18-3409	LUSC	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	0.7237
p.R458K	TCGA-DD-AADO	LIHC	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	0.7237
p.R458K	DO52241	LIHC	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	0.7237
p.R458K	DO26444	LUSC	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	0.7237
p.N457Y	TCGA-50-5946	LUAD	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	0.5948
p.N457Y	DO24556	LUAD	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	0.5948
p.I454V	TCGA-60-2703	LUSC	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	0.25
p.I454V	DO27715	LUSC	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	0.25
p.Q470H	TCGA-A5-A0G1	UCEC	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	0.1944
p.Q470H	DO42472	UCEC	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	0.1944
p.V447L	TCGA-AZ-6601	COAD	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	0.0556
p.V447L	DO8119	COAD	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	0.0556
p.T471S	TCGA-CR-7371	HNSC	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	0.1667
p.T471S	DO15454	HNSC	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	0.1667
p.P466L	TCGA-D3-A8GP	SKCM	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	0.3056
p.P466L	DO51244	SKCM	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	0.3056
p.P462Q	TCGA-G7-6797	KIRP	TCGA	NRWGLPEVD	DEG_APCC_DBOX_1	0.5924
p.P462Q	DO20917	KIRP	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	0.5924
p.E473K	DO229456	SKCA	ICGC	NRWGLPEVD	DEG_APCC_DBOX_1	0.1111
p.E473K	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	NRWGLPEVD	DEG_APCC_DBOX_1	0.1111
p.E473K	ACH-000562	Lung Cancer	CCLE	NRWGLPEVD	DEG_APCC_DBOX_1	0.1111
p.E473K	HCC-78	lung	COSMIC	NRWGLPEVD	DEG_APCC_DBOX_1	0.1111
p.L451F	SIDM00955	Melanoma	GDSC	NRWGLPEVD	DEG_APCC_DBOX_1	0.1667
p.L451F	ACH-000812	Skin Cancer	CCLE	NRWGLPEVD	DEG_APCC_DBOX_1	0.1667
p.L451F	COLO-783	skin	COSMIC	NRWGLPEVD	DEG_APCC_DBOX_1	0.1667
p.A450V	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	NRWGLPEVD	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NRWGLPEVD

Degron related mutations and impact score

Drug responses associated with DPYD mutations

All proteins holding degron of NRWGLPEVD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12882	Dihydropyrimidine dehydrogenase [NADP	DEG_APCC_DBOX_1	457:465	NRWGLPEVD	APC,CDC20,FZR1	0.8315	More...