DegronMD - Q12894(IFRD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P60S	DO51920	BLCA	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	46:53	Mutation rewiring degron network	0.1389
p.P60A	DO51883	BLCA	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	46:53	Mutation rewiring degron network	0.1389
p.V42I	DO8018	COAD	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	46:53	Mutation rewiring degron network	0.2222
p.S52R	DO229036	LICA	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	46:53	Mutation altering degron motif	0.7427
p.P48L	DO23270	LINC	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	46:53	Mutation altering degron motif	0.6471
p.D63Y	DO26300	LUAD	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	46:53	Mutation rewiring degron network	0.0556
p.E46K	DO220886	MELA	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	46:53	Mutation altering degron motif	0.7022
p.S55P	DO231284	PACA	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	46:53	Mutation rewiring degron network	0.2778
p.S38N	DO41999	UCEC	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	46:53	Mutation rewiring degron network	0.1111
p.E56D	DO41361	UCEC	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	46:53	Mutation rewiring degron network	0.25
p.P58L	SIDM00007	Other Solid Cancers	GDSC	LEPTPTGS	DEG_SCF_FBW7_1	46:53	Mutation rewiring degron network	0.1944
p.P58L	ACH-001550	Skin Cancer	CCLE	LEPTPTGS	DEG_SCF_FBW7_1	46:53	Mutation rewiring degron network	0.1944
p.P58L	MCC13	skin	COSMIC	LEPTPTGS	DEG_SCF_FBW7_1	46:53	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons