DegronMD

Uniprot ID: Q12894

Source protein: Interferon-related developmental regulator 2

Source gene: IFRD2

Class: DEG_SCF_FBW7_1

Location: 46:53

E3 ligase: FBXW7

DEGRON score: 0.5348

ASA_SCORE: 87.1125

COIL: 0.9246

CONS_SCORE: 0.2009

DSS_SCORE: 0.7604

HELIX: 0.022

FCONS_SCORE: -0.0009

RIG_SCORE: 0.6076

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P60S	DO51920	BLCA	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	0.1389
p.P60A	DO51883	BLCA	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	0.1389
p.V42I	DO8018	COAD	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	0.2222
p.S52R	DO229036	LICA	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	0.7427
p.P48L	DO23270	LINC	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	0.6471
p.D63Y	DO26300	LUAD	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	0.0556
p.E46K	DO220886	MELA	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	0.7022
p.S55P	DO231284	PACA	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	0.2778
p.S38N	DO41999	UCEC	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	0.1111
p.E56D	DO41361	UCEC	ICGC	LEPTPTGS	DEG_SCF_FBW7_1	0.25
p.P58L	SIDM00007	Other Solid Cancers	GDSC	LEPTPTGS	DEG_SCF_FBW7_1	0.1944
p.P58L	ACH-001550	Skin Cancer	CCLE	LEPTPTGS	DEG_SCF_FBW7_1	0.1944
p.P58L	MCC13	skin	COSMIC	LEPTPTGS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12894	Interferon-related developmental regulator 2	DEG_SCF_FBW7_1	46:53	LEPTPTGS	FBXW7	0.5348	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons