DegronMD - Q12950(FOXD4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R15H	TCGA-49-6761	LUAD	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.7133
p.R15H	TCGA-XK-AAIW	PRAD	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.7133
p.R15H	DO24566	LUAD	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.7133
p.R15H	DO51407	PRAD	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.7133
p.D19Y	TCGA-55-7281	LUAD	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.25
p.D19Y	DO25985	LUAD	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.25
p.E7Q	TCGA-63-A5MS	LUSC	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2778
p.E7Q	DO219161	LUSC	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2778
p.E7Q	ACH-001864	Bile Duct Cancer	CCLE	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2778
p.R10H	TCGA-A5-A0G2	UCEC	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.7133
p.R10H	DO228138	PBCA	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.7133
p.R10H	DO41235	UCEC	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.7133
p.R8C	TCGA-AA-3949	COAD	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.3056
p.R8C	DO7798	COAD	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.3056
p.R8C	SIDM00839	Colorectal Carcinoma	GDSC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.3056
p.R8C	ACH-000950	Colon/Colorectal Cancer	CCLE	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.3056
p.R8C	LoVo	large intestine	COSMIC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.3056
p.R18W	TCGA-AX-A1C5	UCEC	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2778
p.R18W	DO41422	UCEC	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2778
p.L9I	TCGA-B5-A1MX	UCEC	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.6063
p.L9I	DO41999	UCEC	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.6063
p.R5G	TCGA-BS-A0UJ	UCEC	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2222
p.R5G	DO42745	UCEC	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2222
p.R18Q	TCGA-BS-A0UT	UCEC	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2778
p.R18Q	DO43234	UCEC	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2778
p.R10C	TCGA-DA-A1HV	SKCM	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.719
p.R10C	DO37659	SKCM	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.719
p.G22W	TCGA-EC-A1QX	UCEC	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.1667
p.G22W	DO42592	UCEC	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.1667
p.R8H	TCGA-FA-A7Q1	DLBC	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.3056
p.R8H	DO219890	DLBC	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.3056
p.G22E	SIDM01060	Melanoma	GDSC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.1667
p.G22E	IGR-1	skin	COSMIC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.1667
p.R8G	SIDM01018	Hodgkin's Lymphoma	GDSC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.3056
p.R8G	KM-H2	haematopoietic and lymphoid tissue	COSMIC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.3056
p.P13L	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.7582
p.P13L	ACH-000925	Lung Cancer	CCLE	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.7582
p.E7D	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2778
p.D21N	ACH-001061	Colon/Colorectal Cancer	CCLE	LRSTPQRS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOXD4

UniProt ID: Q12950

Entrez ID: 2298

Protein name: Forkhead box protein D4 (Forkhead-related protein FKHL9) (Forkhead-related transcription factor 5) (FREAC-5) (Myeloid factor-alpha)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOXD4 in