DegronMD

Uniprot ID: Q12950

Source protein: Forkhead box protein D4

Source gene: FOXD4

Class: DEG_SCF_FBW7_1

Location: 9:16

E3 ligase: FBXW7

DEGRON score: 0.7376

ASA_SCORE: 94.225

COIL: 0.8456

CONS_SCORE: 0.4655

DSS_SCORE: 0.7002

HELIX: 0.1121

FCONS_SCORE: 0.9903

RIG_SCORE: 0.6391

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R15H	TCGA-49-6761	LUAD	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	0.7133
p.R15H	TCGA-XK-AAIW	PRAD	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	0.7133
p.R15H	DO24566	LUAD	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	0.7133
p.R15H	DO51407	PRAD	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	0.7133
p.D19Y	TCGA-55-7281	LUAD	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	0.25
p.D19Y	DO25985	LUAD	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	0.25
p.E7Q	TCGA-63-A5MS	LUSC	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	0.2778
p.E7Q	DO219161	LUSC	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	0.2778
p.E7Q	ACH-001864	Bile Duct Cancer	CCLE	LRSTPQRS	DEG_SCF_FBW7_1	0.2778
p.R10H	TCGA-A5-A0G2	UCEC	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	0.7133
p.R10H	DO228138	PBCA	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	0.7133
p.R10H	DO41235	UCEC	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	0.7133
p.R8C	TCGA-AA-3949	COAD	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	0.3056
p.R8C	DO7798	COAD	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	0.3056
p.R8C	SIDM00839	Colorectal Carcinoma	GDSC	LRSTPQRS	DEG_SCF_FBW7_1	0.3056
p.R8C	ACH-000950	Colon/Colorectal Cancer	CCLE	LRSTPQRS	DEG_SCF_FBW7_1	0.3056
p.R8C	LoVo	large_intestine	COSMIC	LRSTPQRS	DEG_SCF_FBW7_1	0.3056
p.R18W	TCGA-AX-A1C5	UCEC	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	0.2778
p.R18W	DO41422	UCEC	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	0.2778
p.L9I	TCGA-B5-A1MX	UCEC	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	0.6063
p.L9I	DO41999	UCEC	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	0.6063
p.R5G	TCGA-BS-A0UJ	UCEC	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	0.2222
p.R5G	DO42745	UCEC	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	0.2222
p.R18Q	TCGA-BS-A0UT	UCEC	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	0.2778
p.R18Q	DO43234	UCEC	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	0.2778
p.R10C	TCGA-DA-A1HV	SKCM	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	0.719
p.R10C	DO37659	SKCM	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	0.719
p.G22W	TCGA-EC-A1QX	UCEC	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	0.1667
p.G22W	DO42592	UCEC	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	0.1667
p.R8H	TCGA-FA-A7Q1	DLBC	TCGA	LRSTPQRS	DEG_SCF_FBW7_1	0.3056
p.R8H	DO219890	DLBC	ICGC	LRSTPQRS	DEG_SCF_FBW7_1	0.3056
p.G22E	SIDM01060	Melanoma	GDSC	LRSTPQRS	DEG_SCF_FBW7_1	0.1667
p.G22E	IGR-1	skin	COSMIC	LRSTPQRS	DEG_SCF_FBW7_1	0.1667
p.R8G	SIDM01018	Hodgkin's Lymphoma	GDSC	LRSTPQRS	DEG_SCF_FBW7_1	0.3056
p.R8G	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	LRSTPQRS	DEG_SCF_FBW7_1	0.3056
p.P13L	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	LRSTPQRS	DEG_SCF_FBW7_1	0.7582
p.P13L	ACH-000925	Lung Cancer	CCLE	LRSTPQRS	DEG_SCF_FBW7_1	0.7582
p.E7D	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LRSTPQRS	DEG_SCF_FBW7_1	0.2778
p.D21N	ACH-001061	Colon/Colorectal Cancer	CCLE	LRSTPQRS	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRSTPQRS

Degron related mutations and impact score

Drug responses associated with FOXD4 mutations

All proteins holding degron of LRSTPQRS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3SYB3	Forkhead box protein D4-like 6	DEG_SCF_FBW7_1	9:16	LRSTPQRS	FBXW7	0.884	More...
Q12950	Forkhead box protein D4	DEG_SCF_FBW7_1	9:16	LRSTPQRS	FBXW7	0.7376	More...