DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LRSTPQRS
Uniprot ID:
Q3SYB3
Source protein:
Forkhead box protein D4-like 6
Source gene:
FOXD4L6
Class:
DEG_SCF_FBW7_1
Location:
9:16
E3 ligase:
FBXW7
DEGRON score:
0.884
ASA_SCORE:
99.55
COIL:
0.903
CONS_SCORE:
0.4977
DSS_SCORE:
0.6957
HELIX:
0.0574
FCONS_SCORE:
0.998
RIG_SCORE:
0.6412
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R10C
TCGA-YG-AA3N
SKCM
TCGA
LRSTPQRS
DEG_SCF_FBW7_1
0.719
p.R10C
DO51298
SKCM
ICGC
LRSTPQRS
DEG_SCF_FBW7_1
0.719
Drug responses associated with FOXD4L6 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LRSTPQRS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q3SYB3
Forkhead box protein D4-like 6
DEG_SCF_FBW7_1
9:16
LRSTPQRS
FBXW7
0.884
More...
Q12950
Forkhead box protein D4
DEG_SCF_FBW7_1
9:16
LRSTPQRS
FBXW7
0.7376
More...