PPP1R8
UniProt ID: Q12972
Entrez ID: 5511
Protein name: Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)]
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required...
FUNCTION: Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.; FUNCTION: Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.
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GO - Biological processes (BP):
cell population proliferation [GO:0008283]; mRNA processing [GO:0006397]; negative regulation of protein dephosphorylation [GO:0035308]; RNA catabolic process [GO:0006401]; RNA splicing [GO:0008380]...
cell population proliferation [GO:0008283]; mRNA processing [GO:0006397]; negative regulation of protein dephosphorylation [GO:0035308]; RNA catabolic process [GO:0006401]; RNA splicing [GO:0008380]
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GO - Molecular function (MF):
DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; mRNA binding [GO:0003729]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; ribonuclease E activity [GO:0008995]; RNA binding [GO:0003723]...
DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; mRNA binding [GO:0003729]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; ribonuclease E activity [GO:0008995]; RNA binding [GO:0003723]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]...
cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]
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PPP1R8
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Kaplan plot for PPP1R8 in
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*NOTE: the Kaplan plots were collected from OncoLnc