DegronMD

Uniprot ID: Q12972

Source protein: Nuclear inhibitor of protein phosphatase 1

Source gene: PPP1R8

Class: DEG_COP1_1

Location: 302:310

E3 ligase: COP1

DEGRON score: 0.9803

ASA_SCORE: 81.9444

COIL: 0.9523

CONS_SCORE: 0.4376

DSS_SCORE: 0.4046

HELIX: 0.017

FCONS_SCORE: 0.943

RIG_SCORE: 0.7611

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D302N	TCGA-HU-A4GH	STAD	TCGA	DLTPVVPSA	DEG_COP1_1	0.6932
p.D302N	DO47743	STAD	ICGC	DLTPVVPSA	DEG_COP1_1	0.6932
p.N318D	DO233855	GACA	ICGC	DLTPVVPSA	DEG_COP1_1	0.1111
p.M292I	SIDM00842	Colorectal Carcinoma	GDSC	DLTPVVPSA	DEG_COP1_1	0.0556
p.M292I	SIDM01052	Ovarian Carcinoma	GDSC	DLTPVVPSA	DEG_COP1_1	0.0556
p.M292I	SIDM01564	Colorectal Carcinoma	GDSC	DLTPVVPSA	DEG_COP1_1	0.0556
p.L303F	ACH-000923	Lymphoma	CCLE	DLTPVVPSA	DEG_COP1_1	0.587

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12972	Nuclear inhibitor of protein phosphatase 1	DEG_COP1_1	302:310	DLTPVVPSA	COP1	0.9803	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons