DegronMD - Q12979(ABR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S359F	TCGA-2W-A8YY	CESC	TCGA	VHPFPD	LIG_APCC_ABBA_1	369:374	Mutation rewiring degron network	0.0556
p.V369A	TCGA-CG-5726	STAD	TCGA	VHPFPD	LIG_APCC_ABBA_1	369:374	Mutation altering degron motif	0.6936
p.K381N	TCGA-D1-A17Q	UCEC	TCGA	VHPFPD	LIG_APCC_ABBA_1	369:374	Mutation substituting flanking lysine	0.25
p.K383Q	TCGA-EO-A3AV	UCEC	TCGA	VHPFPD	LIG_APCC_ABBA_1	369:374	Mutation blocking ubiquitination signal	0.5278
p.R369C	DO9314	COAD	ICGC	VHPFPD	LIG_APCC_ABBA_1	369:374	Mutation altering degron motif	0.8301
p.R365W	DO8288	COAD	ICGC	VHPFPD	LIG_APCC_ABBA_1	369:374	Mutation rewiring degron network	0.2222
p.R365L	DO37523	SKCM	ICGC	VHPFPD	LIG_APCC_ABBA_1	369:374	Mutation rewiring degron network	0.2222
p.R369H	SNU-1040	large intestine	COSMIC	VHPFPD	LIG_APCC_ABBA_1	369:374	Mutation altering degron motif	0.8244
p.R360H	SNU-1040	large intestine	COSMIC	VHPFPD	LIG_APCC_ABBA_1	369:374	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons