DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
VHPFPD
Uniprot ID:
Q12979
Source protein:
Active breakpoint cluster region-related protein
Source gene:
ABR
Class:
LIG_APCC_ABBA_1
Location:
369:374
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6752
ASA_SCORE:
76.75
COIL:
0.7975
CONS_SCORE:
0.4014
DSS_SCORE:
0.6564
HELIX:
0.1805
FCONS_SCORE:
0.9821
RIG_SCORE:
0.6657
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S359F
TCGA-2W-A8YY
CESC
TCGA
VHPFPD
LIG_APCC_ABBA_1
0.0556
p.V369A
TCGA-CG-5726
STAD
TCGA
VHPFPD
LIG_APCC_ABBA_1
0.6936
p.K381N
TCGA-D1-A17Q
UCEC
TCGA
VHPFPD
LIG_APCC_ABBA_1
0.25
p.K383Q
TCGA-EO-A3AV
UCEC
TCGA
VHPFPD
LIG_APCC_ABBA_1
0.5278
p.R369C
DO9314
COAD
ICGC
VHPFPD
LIG_APCC_ABBA_1
0.8301
p.R365W
DO8288
COAD
ICGC
VHPFPD
LIG_APCC_ABBA_1
0.2222
p.R365L
DO37523
SKCM
ICGC
VHPFPD
LIG_APCC_ABBA_1
0.2222
p.R369H
SNU-1040
large_intestine
COSMIC
VHPFPD
LIG_APCC_ABBA_1
0.8244
p.R360H
SNU-1040
large_intestine
COSMIC
VHPFPD
LIG_APCC_ABBA_1
0.0833
Drug responses associated with ABR mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VHPFPD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q12979
Active breakpoint cluster region-related protein
LIG_APCC_ABBA_1
369:374
VHPFPD
APC,CDC20,FZR1
0.6752
More...