DegronMD

Uniprot ID: Q12979

Source protein: Active breakpoint cluster region-related protein

Source gene: ABR

Class: LIG_APCC_ABBA_1

Location: 369:374

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6752

ASA_SCORE: 76.75

COIL: 0.7975

CONS_SCORE: 0.4014

DSS_SCORE: 0.6564

HELIX: 0.1805

FCONS_SCORE: 0.9821

RIG_SCORE: 0.6657

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R369C	DO9314	COAD	ICGC	VHPFPD	LIG_APCC_ABBA_1	0.8301
p.R369H	SNU-1040	large_intestine	COSMIC	VHPFPD	LIG_APCC_ABBA_1	0.8244
p.V369A	TCGA-CG-5726	STAD	TCGA	VHPFPD	LIG_APCC_ABBA_1	0.6936
p.K383Q	TCGA-EO-A3AV	UCEC	TCGA	VHPFPD	LIG_APCC_ABBA_1	0.5278
p.K381N	TCGA-D1-A17Q	UCEC	TCGA	VHPFPD	LIG_APCC_ABBA_1	0.25
p.R365W	DO8288	COAD	ICGC	VHPFPD	LIG_APCC_ABBA_1	0.2222
p.R365L	DO37523	SKCM	ICGC	VHPFPD	LIG_APCC_ABBA_1	0.2222
p.R360H	SNU-1040	large_intestine	COSMIC	VHPFPD	LIG_APCC_ABBA_1	0.0833
p.S359F	TCGA-2W-A8YY	CESC	TCGA	VHPFPD	LIG_APCC_ABBA_1	0.0556

Showing 1 to 9 of 9 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12979	Active breakpoint cluster region-related protein	LIG_APCC_ABBA_1	369:374	VHPFPD	APC,CDC20,FZR1	0.6752	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons