DegronMD - Q12986(NFX1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L1007I	TCGA-55-6979	LUAD	TCGA	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation rewiring degron network	0.0833
p.L1007I	DO24110	LUAD	ICGC	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation rewiring degron network	0.0833
p.V1008M	TCGA-95-7039	LUAD	TCGA	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation rewiring degron network	0.0556
p.V1008M	DO23907	LUAD	ICGC	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation rewiring degron network	0.0556
p.V1008M	SIDM00454	Rhabdomyosarcoma	GDSC	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation rewiring degron network	0.0556
p.V1008M	ACH-000689	Sarcoma	CCLE	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation rewiring degron network	0.0556
p.V1008M	RH-18	soft tissue	COSMIC	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation rewiring degron network	0.0556
p.S983I	TCGA-D8-A1JM	BRCA	TCGA	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation rewiring degron network	0.1389
p.S983I	DO2497	BRCA	ICGC	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation rewiring degron network	0.1389
p.A990T	TCGA-L5-A8NE	ESCA	TCGA	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation altering degron motif	0.6028
p.K992N	TCGA-VS-A9UA	CESC	TCGA	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation altering degron motif	0.5806
p.K992N	DO219730	CESC	ICGC	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation altering degron motif	0.5806
p.V1000F	DO229031	LICA	ICGC	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation rewiring degron network	0.2778
p.K995N	DO229037	LICA	ICGC	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation altering degron motif	0.5806
p.V997F	DO229037	LICA	ICGC	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation altering degron motif	0.7068
p.M1004I	DO45207	LIRI	ICGC	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation rewiring degron network	0.1667
p.K981T	SIDM00193	Colorectal Carcinoma	GDSC	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation blocking ubiquitination signal	0.5278
p.K981T	ACH-000991	Colon/Colorectal Cancer	CCLE	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation blocking ubiquitination signal	0.5278
p.K981T	SNU-81	large intestine	COSMIC	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation blocking ubiquitination signal	0.5278
p.V1000I	SIDM00259	Neuroblastoma	GDSC	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation rewiring degron network	0.2778
p.V1000I	SIDM00121	T-Lymphoblastic Leukemia	GDSC	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation rewiring degron network	0.2778
p.V1000I	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ARKDLKFVS	DEG_APCC_DBOX_1	990:998	Mutation rewiring degron network	0.2778

Kaplan plot for NFX1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFX1

UniProt ID: Q12986

Entrez ID: 4799

Protein name: Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NFX1 in