DegronMD

Uniprot ID: Q12986

Source protein: Transcriptional repressor NF-X1

Source gene: NFX1

Class: DEG_APCC_DBOX_1

Location: 990:998

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8214

ASA_SCORE: 61.5667

COIL: 0.1857

CONS_SCORE: 0.3772

DSS_SCORE: 0.3569

HELIX: 0.8136

FCONS_SCORE: 1.0082

RIG_SCORE: 0.7827

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1007I	TCGA-55-6979	LUAD	TCGA	ARKDLKFVS	DEG_APCC_DBOX_1	0.0833
p.L1007I	DO24110	LUAD	ICGC	ARKDLKFVS	DEG_APCC_DBOX_1	0.0833
p.V1008M	TCGA-95-7039	LUAD	TCGA	ARKDLKFVS	DEG_APCC_DBOX_1	0.0556
p.V1008M	DO23907	LUAD	ICGC	ARKDLKFVS	DEG_APCC_DBOX_1	0.0556
p.V1008M	SIDM00454	Rhabdomyosarcoma	GDSC	ARKDLKFVS	DEG_APCC_DBOX_1	0.0556
p.V1008M	ACH-000689	Sarcoma	CCLE	ARKDLKFVS	DEG_APCC_DBOX_1	0.0556
p.V1008M	RH-18	soft_tissue	COSMIC	ARKDLKFVS	DEG_APCC_DBOX_1	0.0556
p.S983I	TCGA-D8-A1JM	BRCA	TCGA	ARKDLKFVS	DEG_APCC_DBOX_1	0.1389
p.S983I	DO2497	BRCA	ICGC	ARKDLKFVS	DEG_APCC_DBOX_1	0.1389
p.A990T	TCGA-L5-A8NE	ESCA	TCGA	ARKDLKFVS	DEG_APCC_DBOX_1	0.6028
p.K992N	TCGA-VS-A9UA	CESC	TCGA	ARKDLKFVS	DEG_APCC_DBOX_1	0.5806
p.K992N	DO219730	CESC	ICGC	ARKDLKFVS	DEG_APCC_DBOX_1	0.5806
p.V1000F	DO229031	LICA	ICGC	ARKDLKFVS	DEG_APCC_DBOX_1	0.2778
p.K995N	DO229037	LICA	ICGC	ARKDLKFVS	DEG_APCC_DBOX_1	0.5806
p.V997F	DO229037	LICA	ICGC	ARKDLKFVS	DEG_APCC_DBOX_1	0.7068
p.M1004I	DO45207	LIRI	ICGC	ARKDLKFVS	DEG_APCC_DBOX_1	0.1667
p.K981T	SIDM00193	Colorectal Carcinoma	GDSC	ARKDLKFVS	DEG_APCC_DBOX_1	0.5278
p.K981T	ACH-000991	Colon/Colorectal Cancer	CCLE	ARKDLKFVS	DEG_APCC_DBOX_1	0.5278
p.K981T	SNU-81	large_intestine	COSMIC	ARKDLKFVS	DEG_APCC_DBOX_1	0.5278
p.V1000I	SIDM00259	Neuroblastoma	GDSC	ARKDLKFVS	DEG_APCC_DBOX_1	0.2778
p.V1000I	SIDM00121	T-Lymphoblastic Leukemia	GDSC	ARKDLKFVS	DEG_APCC_DBOX_1	0.2778
p.V1000I	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ARKDLKFVS	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12986	Transcriptional repressor NF-X1	DEG_APCC_DBOX_1	990:998	ARKDLKFVS	APC,CDC20,FZR1	0.8214	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons