DegronMD - Q13009(TIAM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R363L	TCGA-22-A5C4	LUSC	TCGA	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.1667
p.R363L	DO45446	LUSC	ICGC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.1667
p.E385K	TCGA-AA-A00N	COAD	TCGA	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.0556
p.E385K	DO9876	COAD	ICGC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.0556
p.G371D	TCGA-AP-A1DK	UCEC	TCGA	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation altering degron motif	0.7198
p.G371D	DO42033	UCEC	ICGC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation altering degron motif	0.7198
p.R380H	TCGA-DC-6155	READ	TCGA	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.1944
p.R380H	DO36953	READ	ICGC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.1944
p.G367S	TCGA-EB-A6QZ	SKCM	TCGA	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.2778
p.G367S	DO48626	SKCM	ICGC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.2778
p.A378V	TCGA-IB-7651	PAAD	TCGA	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.25
p.A378V	DO46657	PAAD	ICGC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.25
p.D369N	TCGA-PE-A5DC	BRCA	TCGA	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation altering degron motif	0.6932
p.D369N	DO219641	BRCA	ICGC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation altering degron motif	0.6932
p.S370R	DO229038	LICA	ICGC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation altering degron motif	0.8538
p.T361A	DO35442	PACA	ICGC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.1111
p.S374C	SIDM00281	Other Solid Cancers	GDSC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation altering degron motif	0.643
p.S374C	ACH-002100	Skin Cancer	CCLE	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation altering degron motif	0.643
p.S374C	DJM-1	skin	COSMIC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation altering degron motif	0.643
p.G376R	SIDM00282	Colorectal Carcinoma	GDSC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.3056
p.G376R	ACH-000998	Colon/Colorectal Cancer	CCLE	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.3056
p.G376R	CW-2	large intestine	COSMIC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.3056
p.G382W	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.1389
p.G382W	NCI-H23	lung	COSMIC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.1389
p.Q381H	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.1667
p.Q381H	ACH-000900	Lung Cancer	CCLE	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.1667
p.Q381H	NCI-H23	lung	COSMIC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.1667
p.V383L	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.1111
p.V383L	ACH-000912	Lung Cancer	CCLE	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.1111
p.381_382QG>HW	ACH-000900	Lung Cancer	CCLE	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0
p.D382Y	NCI-H64	lung	COSMIC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.1389
p.A383S	NCI-H1869	lung	COSMIC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.1111
p.R363I	CAL-12T	lung	COSMIC	DSGSSST	DEG_SCF_TRCP1_1	369:375	Mutation rewiring degron network	0.1667

Kaplan plot for TIAM1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TIAM1

UniProt ID: Q13009

Entrez ID: 7074

Protein name: Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TIAM1 in