DegronMD

Uniprot ID: Q13009

Source protein: Rho guanine nucleotide exchange factor TIAM1

Source gene: TIAM1

Class: DEG_SCF_TRCP1_1

Location: 369:375

E3 ligase: BTRC

DEGRON score: 0.9971

ASA_SCORE: 80.3143

COIL: 0.8999

CONS_SCORE: 0.5752

DSS_SCORE: 0.5523

HELIX: 0.0421

FCONS_SCORE: 1.2813

RIG_SCORE: 0.5537

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R363L	TCGA-22-A5C4	LUSC	TCGA	DSGSSST	DEG_SCF_TRCP1_1	0.1667
p.R363L	DO45446	LUSC	ICGC	DSGSSST	DEG_SCF_TRCP1_1	0.1667
p.E385K	TCGA-AA-A00N	COAD	TCGA	DSGSSST	DEG_SCF_TRCP1_1	0.0556
p.E385K	DO9876	COAD	ICGC	DSGSSST	DEG_SCF_TRCP1_1	0.0556
p.G371D	TCGA-AP-A1DK	UCEC	TCGA	DSGSSST	DEG_SCF_TRCP1_1	0.7198
p.G371D	DO42033	UCEC	ICGC	DSGSSST	DEG_SCF_TRCP1_1	0.7198
p.R380H	TCGA-DC-6155	READ	TCGA	DSGSSST	DEG_SCF_TRCP1_1	0.1944
p.R380H	DO36953	READ	ICGC	DSGSSST	DEG_SCF_TRCP1_1	0.1944
p.G367S	TCGA-EB-A6QZ	SKCM	TCGA	DSGSSST	DEG_SCF_TRCP1_1	0.2778
p.G367S	DO48626	SKCM	ICGC	DSGSSST	DEG_SCF_TRCP1_1	0.2778
p.A378V	TCGA-IB-7651	PAAD	TCGA	DSGSSST	DEG_SCF_TRCP1_1	0.25
p.A378V	DO46657	PAAD	ICGC	DSGSSST	DEG_SCF_TRCP1_1	0.25
p.D369N	TCGA-PE-A5DC	BRCA	TCGA	DSGSSST	DEG_SCF_TRCP1_1	0.6932
p.D369N	DO219641	BRCA	ICGC	DSGSSST	DEG_SCF_TRCP1_1	0.6932
p.S370R	DO229038	LICA	ICGC	DSGSSST	DEG_SCF_TRCP1_1	0.8538
p.T361A	DO35442	PACA	ICGC	DSGSSST	DEG_SCF_TRCP1_1	0.1111
p.S374C	SIDM00281	Other Solid Cancers	GDSC	DSGSSST	DEG_SCF_TRCP1_1	0.643
p.S374C	ACH-002100	Skin Cancer	CCLE	DSGSSST	DEG_SCF_TRCP1_1	0.643
p.S374C	DJM-1	skin	COSMIC	DSGSSST	DEG_SCF_TRCP1_1	0.643
p.G376R	SIDM00282	Colorectal Carcinoma	GDSC	DSGSSST	DEG_SCF_TRCP1_1	0.3056
p.G376R	ACH-000998	Colon/Colorectal Cancer	CCLE	DSGSSST	DEG_SCF_TRCP1_1	0.3056
p.G376R	CW-2	large_intestine	COSMIC	DSGSSST	DEG_SCF_TRCP1_1	0.3056
p.G382W	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	DSGSSST	DEG_SCF_TRCP1_1	0.1389
p.G382W	NCI-H23	lung	COSMIC	DSGSSST	DEG_SCF_TRCP1_1	0.1389
p.Q381H	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	DSGSSST	DEG_SCF_TRCP1_1	0.1667
p.Q381H	ACH-000900	Lung Cancer	CCLE	DSGSSST	DEG_SCF_TRCP1_1	0.1667
p.Q381H	NCI-H23	lung	COSMIC	DSGSSST	DEG_SCF_TRCP1_1	0.1667
p.V383L	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	DSGSSST	DEG_SCF_TRCP1_1	0.1111
p.V383L	ACH-000912	Lung Cancer	CCLE	DSGSSST	DEG_SCF_TRCP1_1	0.1111
p.381_382QG>HW	ACH-000900	Lung Cancer	CCLE	DSGSSST	DEG_SCF_TRCP1_1	0
p.D382Y	NCI-H64	lung	COSMIC	DSGSSST	DEG_SCF_TRCP1_1	0.1389
p.A383S	NCI-H1869	lung	COSMIC	DSGSSST	DEG_SCF_TRCP1_1	0.1111
p.R363I	CAL-12T	lung	COSMIC	DSGSSST	DEG_SCF_TRCP1_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGSSST

Degron related mutations and impact score

Drug responses associated with TIAM1 mutations

All proteins holding degron of DSGSSST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13009	Rho guanine nucleotide exchange factor TIAM1	DEG_SCF_TRCP1_1	369:375	DSGSSST	BTRC	0.9971	More...