DegronMD - Q13042(CDC16)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L580R	TCGA-A6-6780	COAD	TCGA	LTPLET	DEG_SCF_FBW7_1	580:585	Mutation altering degron motif	0.8428
p.L580R	DO10244	COAD	ICGC	LTPLET	DEG_SCF_FBW7_1	580:585	Mutation altering degron motif	0.8428
p.T578M	TCGA-EY-A215	UCEC	TCGA	LTPLET	DEG_SCF_FBW7_1	580:585	Mutation rewiring degron network	0.2778
p.T578M	DO42665	UCEC	ICGC	LTPLET	DEG_SCF_FBW7_1	580:585	Mutation rewiring degron network	0.2778
p.T578M	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LTPLET	DEG_SCF_FBW7_1	580:585	Mutation rewiring degron network	0.2778
p.T578M	ACH-002222	Leukemia	CCLE	LTPLET	DEG_SCF_FBW7_1	580:585	Mutation rewiring degron network	0.2778
p.T578M	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LTPLET	DEG_SCF_FBW7_1	580:585	Mutation rewiring degron network	0.2778
p.S595F	DO233818	GACA	ICGC	LTPLET	DEG_SCF_FBW7_1	580:585	Mutation blocking phosphorylation signal	0.5
p.S592Y	SIDM00193	Colorectal Carcinoma	GDSC	LTPLET	DEG_SCF_FBW7_1	580:585	Mutation rewiring degron network	0.1389
p.S592Y	ACH-000991	Colon/Colorectal Cancer	CCLE	LTPLET	DEG_SCF_FBW7_1	580:585	Mutation rewiring degron network	0.1389
p.S592Y	SNU-81	large intestine	COSMIC	LTPLET	DEG_SCF_FBW7_1	580:585	Mutation rewiring degron network	0.1389
p.A575V	SIDM01617	Endometrial Carcinoma	GDSC	LTPLET	DEG_SCF_FBW7_1	580:585	Mutation rewiring degron network	0.1944
p.A575V	ACH-000994	Endometrial/Uterine Cancer	CCLE	LTPLET	DEG_SCF_FBW7_1	580:585	Mutation rewiring degron network	0.1944
p.E577G	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	LTPLET	DEG_SCF_FBW7_1	580:585	Mutation rewiring degron network	0.25
p.E577G	ACH-000925	Lung Cancer	CCLE	LTPLET	DEG_SCF_FBW7_1	580:585	Mutation rewiring degron network	0.25
p.T577M	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LTPLET	DEG_SCF_FBW7_1	580:585	Mutation rewiring degron network	0.25
p.S591Y	SNU-81	large intestine	COSMIC	LTPLET	DEG_SCF_FBW7_1	580:585	Mutation rewiring degron network	0.1667

Kaplan plot for CDC16 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDC16

UniProt ID: Q13042

Entrez ID: 8881

Protein name: Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDC16 in