DegronMD

Uniprot ID: Q13042

Source protein: Cell division cycle protein 16 homolog

Source gene: CDC16

Class: DEG_SCF_FBW7_1

Location: 580:585

E3 ligase: FBXW7

DEGRON score: 0.9729

ASA_SCORE: 50

COIL: 0.5458

CONS_SCORE: 0.2763

DSS_SCORE: 0.6919

HELIX: 0.4098

FCONS_SCORE: 1.1167

RIG_SCORE: 0.6952

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L580R	TCGA-A6-6780	COAD	TCGA	LTPLET	DEG_SCF_FBW7_1	0.8428
p.L580R	DO10244	COAD	ICGC	LTPLET	DEG_SCF_FBW7_1	0.8428
p.S595F	DO233818	GACA	ICGC	LTPLET	DEG_SCF_FBW7_1	0.5
p.T578M	TCGA-EY-A215	UCEC	TCGA	LTPLET	DEG_SCF_FBW7_1	0.2778
p.T578M	DO42665	UCEC	ICGC	LTPLET	DEG_SCF_FBW7_1	0.2778
p.T578M	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LTPLET	DEG_SCF_FBW7_1	0.2778
p.T578M	ACH-002222	Leukemia	CCLE	LTPLET	DEG_SCF_FBW7_1	0.2778
p.T578M	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LTPLET	DEG_SCF_FBW7_1	0.2778
p.E577G	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	LTPLET	DEG_SCF_FBW7_1	0.25
p.E577G	ACH-000925	Lung Cancer	CCLE	LTPLET	DEG_SCF_FBW7_1	0.25
p.T577M	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LTPLET	DEG_SCF_FBW7_1	0.25
p.A575V	SIDM01617	Endometrial Carcinoma	GDSC	LTPLET	DEG_SCF_FBW7_1	0.1944
p.A575V	ACH-000994	Endometrial/Uterine Cancer	CCLE	LTPLET	DEG_SCF_FBW7_1	0.1944
p.S591Y	SNU-81	large_intestine	COSMIC	LTPLET	DEG_SCF_FBW7_1	0.1667
p.S592Y	SIDM00193	Colorectal Carcinoma	GDSC	LTPLET	DEG_SCF_FBW7_1	0.1389
p.S592Y	ACH-000991	Colon/Colorectal Cancer	CCLE	LTPLET	DEG_SCF_FBW7_1	0.1389
p.S592Y	SNU-81	large_intestine	COSMIC	LTPLET	DEG_SCF_FBW7_1	0.1389

Showing 1 to 17 of 17 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13042	Cell division cycle protein 16 homolog	DEG_SCF_FBW7_1	580:585	LTPLET	FBXW7	0.9729	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons