DegronMD - Q13045(FLII)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R42L	TCGA-BA-A4IF	HNSC	TCGA	NRTGLCYLP	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.8428
p.R42L	DO234237	ESAD	ICGC	NRTGLCYLP	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.8428
p.R42L	DO49043	HNSC	ICGC	NRTGLCYLP	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.8428
p.A54T	TCGA-Q1-A5R2	CESC	TCGA	NRTGLCYLP	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1944
p.A54T	DO49003	CESC	ICGC	NRTGLCYLP	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1944
p.Q56R	TCGA-SX-A71S	KIRP	TCGA	NRTGLCYLP	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.Q56R	DO49778	KIRP	ICGC	NRTGLCYLP	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.P49T	DO228974	LICA	ICGC	NRTGLCYLP	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.5919
p.S34R	DO228985	LICA	ICGC	NRTGLCYLP	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.T59M	DO41361	UCEC	ICGC	NRTGLCYLP	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.0556
p.S34N	SIDM00217	Colorectal Carcinoma	GDSC	NRTGLCYLP	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.S34N	ACH-000999	Colon/Colorectal Cancer	CCLE	NRTGLCYLP	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.S34N	SNU-1040	large intestine	COSMIC	NRTGLCYLP	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.A53V	SIDM00500	Colorectal Carcinoma	GDSC	NRTGLCYLP	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2222
p.A53V	ACH-000959	Colon/Colorectal Cancer	CCLE	NRTGLCYLP	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2222

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons