DegronMD

Uniprot ID: Q13045

Source protein: Protein flightless-1 homolog

Source gene: FLII

Class: DEG_APCC_DBOX_1

Location: 41:49

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7971

ASA_SCORE: 50.9

COIL: 0.799

CONS_SCORE: 0.468

DSS_SCORE: 0.0551

HELIX: 0.0314

FCONS_SCORE: 0.892

RIG_SCORE: 0.888

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R42L	TCGA-BA-A4IF	HNSC	TCGA	NRTGLCYLP	DEG_APCC_DBOX_1	0.8428
p.R42L	DO234237	ESAD	ICGC	NRTGLCYLP	DEG_APCC_DBOX_1	0.8428
p.R42L	DO49043	HNSC	ICGC	NRTGLCYLP	DEG_APCC_DBOX_1	0.8428
p.A54T	TCGA-Q1-A5R2	CESC	TCGA	NRTGLCYLP	DEG_APCC_DBOX_1	0.1944
p.A54T	DO49003	CESC	ICGC	NRTGLCYLP	DEG_APCC_DBOX_1	0.1944
p.Q56R	TCGA-SX-A71S	KIRP	TCGA	NRTGLCYLP	DEG_APCC_DBOX_1	0.1389
p.Q56R	DO49778	KIRP	ICGC	NRTGLCYLP	DEG_APCC_DBOX_1	0.1389
p.P49T	DO228974	LICA	ICGC	NRTGLCYLP	DEG_APCC_DBOX_1	0.5919
p.S34R	DO228985	LICA	ICGC	NRTGLCYLP	DEG_APCC_DBOX_1	0.1389
p.T59M	DO41361	UCEC	ICGC	NRTGLCYLP	DEG_APCC_DBOX_1	0.0556
p.S34N	SIDM00217	Colorectal Carcinoma	GDSC	NRTGLCYLP	DEG_APCC_DBOX_1	0.1389
p.S34N	ACH-000999	Colon/Colorectal Cancer	CCLE	NRTGLCYLP	DEG_APCC_DBOX_1	0.1389
p.S34N	SNU-1040	large_intestine	COSMIC	NRTGLCYLP	DEG_APCC_DBOX_1	0.1389
p.A53V	SIDM00500	Colorectal Carcinoma	GDSC	NRTGLCYLP	DEG_APCC_DBOX_1	0.2222
p.A53V	ACH-000959	Colon/Colorectal Cancer	CCLE	NRTGLCYLP	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13045	Protein flightless-1 homolog	DEG_APCC_DBOX_1	41:49	NRTGLCYLP	APC,CDC20,FZR1	0.7971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons