DegronMD - Q13061(TRDN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T594A	TCGA-63-7022	LUSC	TCGA	PKPTPKGT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.25
p.T594A	DO26470	LUSC	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.25
p.S591Y	TCGA-B5-A1MR	UCEC	TCGA	PKPTPKGT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.1667
p.S591Y	DO41758	UCEC	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.1667
p.K598T	TCGA-EO-A22U	UCEC	TCGA	PKPTPKGT	DEG_SCF_FBW7_1	597:604	Mutation altering degron motif	0.6195
p.K598T	DO43755	UCEC	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	597:604	Mutation altering degron motif	0.6195
p.R587K	TCGA-GN-A8LK	SKCM	TCGA	PKPTPKGT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.0556
p.R587K	DO51259	SKCM	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.0556
p.G611V	TCGA-PE-A5DE	BRCA	TCGA	PKPTPKGT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.1389
p.G611V	DO219643	BRCA	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.1389
p.D595G	DO23222	LINC	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.2778
p.K612T	DO222843	MELA	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	597:604	Mutation substituting flanking lysine	0.2222
p.G611A	DO219878	SKCA	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.1389
p.P601A	DO229459	SKCA	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	597:604	Mutation altering degron motif	0.7503
p.E609K	DO37432	SKCM	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.1944
p.G603R	SIDM00545	Melanoma	GDSC	PKPTPKGT	DEG_SCF_FBW7_1	597:604	Mutation altering degron motif	0.6457
p.D595Y	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PKPTPKGT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.2778
p.D595Y	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PKPTPKGT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.2778

Kaplan plot for TRDN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRDN

UniProt ID: Q13061

Entrez ID: 10345

Protein name: Triadin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRDN in