DegronMD

Uniprot ID: Q13061

Source protein: Triadin

Source gene: TRDN

Class: DEG_SCF_FBW7_1

Location: 597:604

E3 ligase: FBXW7

DEGRON score: 0.9389

ASA_SCORE: 101.2375

COIL: 0.963

CONS_SCORE: 0.3762

DSS_SCORE: 0.7271

HELIX: 0.0188

FCONS_SCORE: 1.0068

RIG_SCORE: 0.531

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T594A	TCGA-63-7022	LUSC	TCGA	PKPTPKGT	DEG_SCF_FBW7_1	0.25
p.T594A	DO26470	LUSC	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	0.25
p.S591Y	TCGA-B5-A1MR	UCEC	TCGA	PKPTPKGT	DEG_SCF_FBW7_1	0.1667
p.S591Y	DO41758	UCEC	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	0.1667
p.K598T	TCGA-EO-A22U	UCEC	TCGA	PKPTPKGT	DEG_SCF_FBW7_1	0.6195
p.K598T	DO43755	UCEC	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	0.6195
p.R587K	TCGA-GN-A8LK	SKCM	TCGA	PKPTPKGT	DEG_SCF_FBW7_1	0.0556
p.R587K	DO51259	SKCM	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	0.0556
p.G611V	TCGA-PE-A5DE	BRCA	TCGA	PKPTPKGT	DEG_SCF_FBW7_1	0.1389
p.G611V	DO219643	BRCA	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	0.1389
p.D595G	DO23222	LINC	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	0.2778
p.K612T	DO222843	MELA	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	0.2222
p.G611A	DO219878	SKCA	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	0.1389
p.P601A	DO229459	SKCA	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	0.7503
p.E609K	DO37432	SKCM	ICGC	PKPTPKGT	DEG_SCF_FBW7_1	0.1944
p.G603R	SIDM00545	Melanoma	GDSC	PKPTPKGT	DEG_SCF_FBW7_1	0.6457
p.D595Y	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PKPTPKGT	DEG_SCF_FBW7_1	0.2778
p.D595Y	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PKPTPKGT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13061	Triadin	DEG_SCF_FBW7_1	597:604	PKPTPKGT	FBXW7	0.9389	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons