DegronMD - Q13085(ACACA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R2166H	TCGA-A2-A0SU	BRCA	TCGA	LGTPELS	DEG_SCF_FBW7_1	2151:2157	Mutation rewiring degron network	0.0833
p.R2166C	TCGA-B5-A3FA	UCEC	TCGA	LGTPELS	DEG_SCF_FBW7_1	2151:2157	Mutation rewiring degron network	0.0833
p.R2166C	DO52402	UCEC	ICGC	LGTPELS	DEG_SCF_FBW7_1	2151:2157	Mutation rewiring degron network	0.0833
p.L2155V	TCGA-CF-A47V	BLCA	TCGA	LGTPELS	DEG_SCF_FBW7_1	2151:2157	Mutation altering degron motif	0.6765
p.R2148L	TCGA-D3-A2J6	SKCM	TCGA	LGTPELS	DEG_SCF_FBW7_1	2151:2157	Mutation rewiring degron network	0.25
p.R2148L	DO37901	SKCM	ICGC	LGTPELS	DEG_SCF_FBW7_1	2151:2157	Mutation rewiring degron network	0.25
p.S2153T	TCGA-VQ-A8PP	STAD	TCGA	LGTPELS	DEG_SCF_FBW7_1	2151:2157	Mutation altering degron motif	0.7116
p.S2153T	DO51774	STAD	ICGC	LGTPELS	DEG_SCF_FBW7_1	2151:2157	Mutation altering degron motif	0.7116
p.D2163H	DO51599	CESC	ICGC	LGTPELS	DEG_SCF_FBW7_1	2151:2157	Mutation rewiring degron network	0.1667
p.R2143H	DO233942	GACA	ICGC	LGTPELS	DEG_SCF_FBW7_1	2151:2157	Mutation rewiring degron network	0.1111
p.Q2167P	DO23442	LINC	ICGC	LGTPELS	DEG_SCF_FBW7_1	2151:2157	Mutation substituting flanking lysine	0.1667
p.R2143C	DO41871	UCEC	ICGC	LGTPELS	DEG_SCF_FBW7_1	2151:2157	Mutation rewiring degron network	0.1111
p.R2143C	DO43971	UCEC	ICGC	LGTPELS	DEG_SCF_FBW7_1	2151:2157	Mutation rewiring degron network	0.1111
p.R2167K	SIDM00845	Burkitt's Lymphoma	GDSC	LGTPELS	DEG_SCF_FBW7_1	2151:2157	Mutation substituting flanking lysine	0.1667
p.R2167K	SIDM01519	Head and Neck Carcinoma	GDSC	LGTPELS	DEG_SCF_FBW7_1	2151:2157	Mutation substituting flanking lysine	0.1667
p.R2167G	SIDM00357	Small Cell Lung Carcinoma	GDSC	LGTPELS	DEG_SCF_FBW7_1	2151:2157	Mutation substituting flanking lysine	0.1667
p.M2144L	SIDM01725	Non-Cancerous	GDSC	LGTPELS	DEG_SCF_FBW7_1	2151:2157	Mutation blocking phosphorylation signal	0.5833
p.V2143A	ACH-001518	Endometrial/Uterine Cancer	CCLE	LGTPELS	DEG_SCF_FBW7_1	2151:2157	Mutation rewiring degron network	0.1111

Kaplan plot for ACACA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ACACA

UniProt ID: Q13085

Entrez ID: 31

Protein name: Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ACACA in