DegronMD

Uniprot ID: Q13085

Source protein: Acetyl-CoA carboxylase 1

Source gene: ACACA

Class: DEG_SCF_FBW7_1

Location: 2151:2157

E3 ligase: FBXW7

DEGRON score: 0.7455

ASA_SCORE: 71.1571

COIL: 0.8684

CONS_SCORE: 0.2818

DSS_SCORE: 0.3557

HELIX: 0.1229

FCONS_SCORE: 0.7419

RIG_SCORE: 0.7228

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2166H	TCGA-A2-A0SU	BRCA	TCGA	LGTPELS	DEG_SCF_FBW7_1	0.0833
p.R2166C	TCGA-B5-A3FA	UCEC	TCGA	LGTPELS	DEG_SCF_FBW7_1	0.0833
p.R2166C	DO52402	UCEC	ICGC	LGTPELS	DEG_SCF_FBW7_1	0.0833
p.L2155V	TCGA-CF-A47V	BLCA	TCGA	LGTPELS	DEG_SCF_FBW7_1	0.6765
p.R2148L	TCGA-D3-A2J6	SKCM	TCGA	LGTPELS	DEG_SCF_FBW7_1	0.25
p.R2148L	DO37901	SKCM	ICGC	LGTPELS	DEG_SCF_FBW7_1	0.25
p.S2153T	TCGA-VQ-A8PP	STAD	TCGA	LGTPELS	DEG_SCF_FBW7_1	0.7116
p.S2153T	DO51774	STAD	ICGC	LGTPELS	DEG_SCF_FBW7_1	0.7116
p.D2163H	DO51599	CESC	ICGC	LGTPELS	DEG_SCF_FBW7_1	0.1667
p.R2143H	DO233942	GACA	ICGC	LGTPELS	DEG_SCF_FBW7_1	0.1111
p.Q2167P	DO23442	LINC	ICGC	LGTPELS	DEG_SCF_FBW7_1	0.1667
p.R2143C	DO41871	UCEC	ICGC	LGTPELS	DEG_SCF_FBW7_1	0.1111
p.R2143C	DO43971	UCEC	ICGC	LGTPELS	DEG_SCF_FBW7_1	0.1111
p.R2167K	SIDM00845	Burkitt's Lymphoma	GDSC	LGTPELS	DEG_SCF_FBW7_1	0.1667
p.R2167K	SIDM01519	Head and Neck Carcinoma	GDSC	LGTPELS	DEG_SCF_FBW7_1	0.1667
p.R2167G	SIDM00357	Small Cell Lung Carcinoma	GDSC	LGTPELS	DEG_SCF_FBW7_1	0.1667
p.M2144L	SIDM01725	Non-Cancerous	GDSC	LGTPELS	DEG_SCF_FBW7_1	0.5833
p.V2143A	ACH-001518	Endometrial/Uterine Cancer	CCLE	LGTPELS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13085	Acetyl-CoA carboxylase 1	DEG_SCF_FBW7_1	2151:2157	LGTPELS	FBXW7	0.7455	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons