DegronMD - Q13093(PLA2G7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D401H	TCGA-95-7039	LUAD	TCGA	LGLHKD	LIG_APCC_ABBA_1	396:401	Mutation altering degron motif	0.7688
p.D401H	DO23907	LUAD	ICGC	LGLHKD	LIG_APCC_ABBA_1	396:401	Mutation altering degron motif	0.7688
p.K400T	TCGA-95-7039	LUAD	TCGA	LGLHKD	LIG_APCC_ABBA_1	396:401	Mutation altering degron motif	0.6195
p.K400T	DO23907	LUAD	ICGC	LGLHKD	LIG_APCC_ABBA_1	396:401	Mutation altering degron motif	0.6195
p.D401Y	TCGA-A5-A0G2	UCEC	TCGA	LGLHKD	LIG_APCC_ABBA_1	396:401	Mutation altering degron motif	0.7325
p.D401Y	DO41235	UCEC	ICGC	LGLHKD	LIG_APCC_ABBA_1	396:401	Mutation altering degron motif	0.7325
p.K386T	TCGA-AP-A0LM	UCEC	TCGA	LGLHKD	LIG_APCC_ABBA_1	396:401	Mutation substituting flanking lysine	0.1667
p.K386T	DO43306	UCEC	ICGC	LGLHKD	LIG_APCC_ABBA_1	396:401	Mutation substituting flanking lysine	0.1667
p.H399D	TCGA-DD-A115	LIHC	TCGA	LGLHKD	LIG_APCC_ABBA_1	396:401	Mutation altering degron motif	0.7688
p.H399D	TCGA-DD-A1EE	LIHC	TCGA	LGLHKD	LIG_APCC_ABBA_1	396:401	Mutation altering degron motif	0.7688
p.H399D	DO22911	LIHC	ICGC	LGLHKD	LIG_APCC_ABBA_1	396:401	Mutation altering degron motif	0.7688
p.H399D	DO22857	LIHC	ICGC	LGLHKD	LIG_APCC_ABBA_1	396:401	Mutation altering degron motif	0.7688
p.A387D	TCGA-X6-A7WA	SARC	TCGA	LGLHKD	LIG_APCC_ABBA_1	396:401	Mutation rewiring degron network	0.0833
p.A387D	DO220312	SARC	ICGC	LGLHKD	LIG_APCC_ABBA_1	396:401	Mutation rewiring degron network	0.0833
p.F391L	DO225090	BRCA	ICGC	LGLHKD	LIG_APCC_ABBA_1	396:401	Mutation rewiring degron network	0.1944
p.K394T	DO227996	COCA	ICGC	LGLHKD	LIG_APCC_ABBA_1	396:401	Mutation rewiring degron network	0.2778
p.L389S	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	LGLHKD	LIG_APCC_ABBA_1	396:401	Mutation rewiring degron network	0.1389
p.L389S	SIDM00844	Burkitt's Lymphoma	GDSC	LGLHKD	LIG_APCC_ABBA_1	396:401	Mutation rewiring degron network	0.1389
p.L389S	SIDM00907	Burkitt's Lymphoma	GDSC	LGLHKD	LIG_APCC_ABBA_1	396:401	Mutation rewiring degron network	0.1389

Kaplan plot for PLA2G7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLA2G7

UniProt ID: Q13093

Entrez ID: 7941

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLA2G7 in