DegronMD

Uniprot ID: Q13093

Source protein: Platelet-activating factor acetylhydrolase

Source gene: PLA2G7

Class: LIG_APCC_ABBA_1

Location: 396:401

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5948

ASA_SCORE: 83.2

COIL: 0.8663

CONS_SCORE: 0.288

DSS_SCORE: 0.0488

HELIX: 0.1223

FCONS_SCORE: 0.8358

RIG_SCORE: 0.7935

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D401H	TCGA-95-7039	LUAD	TCGA	LGLHKD	LIG_APCC_ABBA_1	0.7688
p.D401H	DO23907	LUAD	ICGC	LGLHKD	LIG_APCC_ABBA_1	0.7688
p.K400T	TCGA-95-7039	LUAD	TCGA	LGLHKD	LIG_APCC_ABBA_1	0.6195
p.K400T	DO23907	LUAD	ICGC	LGLHKD	LIG_APCC_ABBA_1	0.6195
p.D401Y	TCGA-A5-A0G2	UCEC	TCGA	LGLHKD	LIG_APCC_ABBA_1	0.7325
p.D401Y	DO41235	UCEC	ICGC	LGLHKD	LIG_APCC_ABBA_1	0.7325
p.K386T	TCGA-AP-A0LM	UCEC	TCGA	LGLHKD	LIG_APCC_ABBA_1	0.1667
p.K386T	DO43306	UCEC	ICGC	LGLHKD	LIG_APCC_ABBA_1	0.1667
p.H399D	TCGA-DD-A115	LIHC	TCGA	LGLHKD	LIG_APCC_ABBA_1	0.7688
p.H399D	TCGA-DD-A1EE	LIHC	TCGA	LGLHKD	LIG_APCC_ABBA_1	0.7688
p.H399D	DO22911	LIHC	ICGC	LGLHKD	LIG_APCC_ABBA_1	0.7688
p.H399D	DO22857	LIHC	ICGC	LGLHKD	LIG_APCC_ABBA_1	0.7688
p.A387D	TCGA-X6-A7WA	SARC	TCGA	LGLHKD	LIG_APCC_ABBA_1	0.0833
p.A387D	DO220312	SARC	ICGC	LGLHKD	LIG_APCC_ABBA_1	0.0833
p.F391L	DO225090	BRCA	ICGC	LGLHKD	LIG_APCC_ABBA_1	0.1944
p.K394T	DO227996	COCA	ICGC	LGLHKD	LIG_APCC_ABBA_1	0.2778
p.L389S	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	LGLHKD	LIG_APCC_ABBA_1	0.1389
p.L389S	SIDM00844	Burkitt's Lymphoma	GDSC	LGLHKD	LIG_APCC_ABBA_1	0.1389
p.L389S	SIDM00907	Burkitt's Lymphoma	GDSC	LGLHKD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13093	Platelet-activating factor acetylhydrolase	LIG_APCC_ABBA_1	396:401	LGLHKD	APC,CDC20,FZR1	0.5948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons