DegronMD - Q13098(GPS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R484H	TCGA-2W-A8YY	CESC	TCGA	LTPANS	DEG_SCF_FBW7_1	478:483	Mutation rewiring degron network	0.3056
p.R484H	DO223732	CESC	ICGC	LTPANS	DEG_SCF_FBW7_1	478:483	Mutation rewiring degron network	0.3056
p.R484H	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPANS	DEG_SCF_FBW7_1	478:483	Mutation rewiring degron network	0.3056
p.R484H	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LTPANS	DEG_SCF_FBW7_1	478:483	Mutation rewiring degron network	0.3056
p.R492Q	TCGA-2W-A8YY	CESC	TCGA	LTPANS	DEG_SCF_FBW7_1	478:483	Mutation rewiring degron network	0.0833
p.R492Q	DO223732	CESC	ICGC	LTPANS	DEG_SCF_FBW7_1	478:483	Mutation rewiring degron network	0.0833
p.E473D	TCGA-AP-A1DV	UCEC	TCGA	LTPANS	DEG_SCF_FBW7_1	478:483	Mutation rewiring degron network	0.1944
p.E473D	DO43186	UCEC	ICGC	LTPANS	DEG_SCF_FBW7_1	478:483	Mutation rewiring degron network	0.1944
p.R485C	TCGA-BR-8368	STAD	TCGA	LTPANS	DEG_SCF_FBW7_1	478:483	Mutation blocking phosphorylation signal	0.7222
p.R485C	DO47981	STAD	ICGC	LTPANS	DEG_SCF_FBW7_1	478:483	Mutation blocking phosphorylation signal	0.7222
p.E473Q	TCGA-EK-A3GK	CESC	TCGA	LTPANS	DEG_SCF_FBW7_1	478:483	Mutation rewiring degron network	0.1944
p.E473Q	DO49964	CESC	ICGC	LTPANS	DEG_SCF_FBW7_1	478:483	Mutation rewiring degron network	0.1944
p.R492W	TCGA-NH-A5IV	COAD	TCGA	LTPANS	DEG_SCF_FBW7_1	478:483	Mutation rewiring degron network	0.0833
p.R492W	DO49095	COAD	ICGC	LTPANS	DEG_SCF_FBW7_1	478:483	Mutation rewiring degron network	0.0833
p.A486T	DO222765	COCA	ICGC	LTPANS	DEG_SCF_FBW7_1	478:483	Mutation rewiring degron network	0.25
p.A493V	DO233732	GACA	ICGC	LTPANS	DEG_SCF_FBW7_1	478:483	Mutation rewiring degron network	0.0556
p.M478I	DO229028	LICA	ICGC	LTPANS	DEG_SCF_FBW7_1	478:483	Mutation altering degron motif	0.7618
p.R483H	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LTPANS	DEG_SCF_FBW7_1	478:483	Mutation altering degron motif	0.8244

Kaplan plot for GPS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPS1

UniProt ID: Q13098

Entrez ID: 2873

Protein name: COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPS1 in