DegronMD

Uniprot ID: Q13098

Source protein: COP9 signalosome complex subunit 1

Source gene: GPS1

Class: DEG_SCF_FBW7_1

Location: 478:483

E3 ligase: FBXW7

DEGRON score: 0.9914

ASA_SCORE: 81.75

COIL: 0.7925

CONS_SCORE: 0.3114

DSS_SCORE: 0.8004

HELIX: 0.152

FCONS_SCORE: 0.9879

RIG_SCORE: 0.6257

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R484H	TCGA-2W-A8YY	CESC	TCGA	LTPANS	DEG_SCF_FBW7_1	0.3056
p.R484H	DO223732	CESC	ICGC	LTPANS	DEG_SCF_FBW7_1	0.3056
p.R484H	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPANS	DEG_SCF_FBW7_1	0.3056
p.R484H	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LTPANS	DEG_SCF_FBW7_1	0.3056
p.R492Q	TCGA-2W-A8YY	CESC	TCGA	LTPANS	DEG_SCF_FBW7_1	0.0833
p.R492Q	DO223732	CESC	ICGC	LTPANS	DEG_SCF_FBW7_1	0.0833
p.E473D	TCGA-AP-A1DV	UCEC	TCGA	LTPANS	DEG_SCF_FBW7_1	0.1944
p.E473D	DO43186	UCEC	ICGC	LTPANS	DEG_SCF_FBW7_1	0.1944
p.R485C	TCGA-BR-8368	STAD	TCGA	LTPANS	DEG_SCF_FBW7_1	0.7222
p.R485C	DO47981	STAD	ICGC	LTPANS	DEG_SCF_FBW7_1	0.7222
p.E473Q	TCGA-EK-A3GK	CESC	TCGA	LTPANS	DEG_SCF_FBW7_1	0.1944
p.E473Q	DO49964	CESC	ICGC	LTPANS	DEG_SCF_FBW7_1	0.1944
p.R492W	TCGA-NH-A5IV	COAD	TCGA	LTPANS	DEG_SCF_FBW7_1	0.0833
p.R492W	DO49095	COAD	ICGC	LTPANS	DEG_SCF_FBW7_1	0.0833
p.A486T	DO222765	COCA	ICGC	LTPANS	DEG_SCF_FBW7_1	0.25
p.A493V	DO233732	GACA	ICGC	LTPANS	DEG_SCF_FBW7_1	0.0556
p.M478I	DO229028	LICA	ICGC	LTPANS	DEG_SCF_FBW7_1	0.7618
p.R483H	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LTPANS	DEG_SCF_FBW7_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13098	COP9 signalosome complex subunit 1	DEG_SCF_FBW7_1	478:483	LTPANS	FBXW7	0.9914	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons