DegronMD - Q13099(IFT88)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G759S	TCGA-CG-5728	STAD	TCGA	DSGQNYS	DEG_SCF_TRCP1_1	748:754	Mutation rewiring degron network	0.1944
p.R747C	DO230342	COCA	ICGC	DSGQNYS	DEG_SCF_TRCP1_1	748:754	Mutation rewiring degron network	0.3056
p.G752W	DO229024	LICA	ICGC	DSGQNYS	DEG_SCF_TRCP1_1	748:754	Mutation altering degron motif	0.7825
p.L744F	DO228371	MALY	ICGC	DSGQNYS	DEG_SCF_TRCP1_1	748:754	Mutation blocking phosphorylation signal	0.6667
p.S761R	DO42977	UCEC	ICGC	DSGQNYS	DEG_SCF_TRCP1_1	748:754	Mutation rewiring degron network	0.1389
p.S743I	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	DSGQNYS	DEG_SCF_TRCP1_1	748:754	Mutation rewiring degron network	0.1944
p.S743I	NCI-H1299	lung	COSMIC	DSGQNYS	DEG_SCF_TRCP1_1	748:754	Mutation rewiring degron network	0.1944
p.E751Q	SIDM00092	Ovarian Carcinoma	GDSC	DSGQNYS	DEG_SCF_TRCP1_1	748:754	Mutation altering degron motif	0.6744
p.E751Q	OVCAR-4	ovary	COSMIC	DSGQNYS	DEG_SCF_TRCP1_1	748:754	Mutation altering degron motif	0.6744
p.S755T	SIDM00092	Ovarian Carcinoma	GDSC	DSGQNYS	DEG_SCF_TRCP1_1	748:754	Mutation rewiring degron network	0.3056
p.S755T	OVCAR-4	ovary	COSMIC	DSGQNYS	DEG_SCF_TRCP1_1	748:754	Mutation rewiring degron network	0.3056
p.E742Q	ACH-000617	Ovarian Cancer	CCLE	DSGQNYS	DEG_SCF_TRCP1_1	748:754	Mutation rewiring degron network	0.1667
p.E742Q	OVCAR-4	ovary	COSMIC	DSGQNYS	DEG_SCF_TRCP1_1	748:754	Mutation rewiring degron network	0.1667
p.S746T	ACH-000617	Ovarian Cancer	CCLE	DSGQNYS	DEG_SCF_TRCP1_1	748:754	Mutation rewiring degron network	0.2778
p.S746T	OVCAR-4	ovary	COSMIC	DSGQNYS	DEG_SCF_TRCP1_1	748:754	Mutation rewiring degron network	0.2778
p.G747D	ACH-001031	Rhabdoid	CCLE	DSGQNYS	DEG_SCF_TRCP1_1	748:754	Mutation rewiring degron network	0.3056

Kaplan plot for IFT88 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IFT88

UniProt ID: Q13099

Entrez ID: 8100

Protein name: Intraflagellar transport protein 88 homolog (Recessive polycystic kidney disease protein Tg737 homolog) (Tetratricopeptide repeat protein 10) (TPR repeat protein 10)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for IFT88 in