DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSGQNYS
Uniprot ID:
Q13099
Source protein:
Intraflagellar transport protein 88 homolog
Source gene:
IFT88
Class:
DEG_SCF_TRCP1_1
Location:
748:754
E3 ligase:
BTRC
DEGRON score:
0.9498
ASA_SCORE:
76.8143
COIL:
0.753
CONS_SCORE:
0.29
DSS_SCORE:
0.662
HELIX:
0.211
FCONS_SCORE:
0.9752
RIG_SCORE:
0.5569
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G752W
DO229024
LICA
ICGC
DSGQNYS
DEG_SCF_TRCP1_1
0.7825
p.E751Q
SIDM00092
Ovarian Carcinoma
GDSC
DSGQNYS
DEG_SCF_TRCP1_1
0.6744
p.E751Q
OVCAR-4
ovary
COSMIC
DSGQNYS
DEG_SCF_TRCP1_1
0.6744
p.L744F
DO228371
MALY
ICGC
DSGQNYS
DEG_SCF_TRCP1_1
0.6667
p.R747C
DO230342
COCA
ICGC
DSGQNYS
DEG_SCF_TRCP1_1
0.3056
p.S755T
SIDM00092
Ovarian Carcinoma
GDSC
DSGQNYS
DEG_SCF_TRCP1_1
0.3056
p.S755T
OVCAR-4
ovary
COSMIC
DSGQNYS
DEG_SCF_TRCP1_1
0.3056
p.G747D
ACH-001031
Rhabdoid
CCLE
DSGQNYS
DEG_SCF_TRCP1_1
0.3056
p.S746T
ACH-000617
Ovarian Cancer
CCLE
DSGQNYS
DEG_SCF_TRCP1_1
0.2778
p.S746T
OVCAR-4
ovary
COSMIC
DSGQNYS
DEG_SCF_TRCP1_1
0.2778
p.G759S
TCGA-CG-5728
STAD
TCGA
DSGQNYS
DEG_SCF_TRCP1_1
0.1944
p.S743I
SIDM00649
Non-Small Cell Lung Carcinoma
GDSC
DSGQNYS
DEG_SCF_TRCP1_1
0.1944
p.S743I
NCI-H1299
lung
COSMIC
DSGQNYS
DEG_SCF_TRCP1_1
0.1944
p.E742Q
ACH-000617
Ovarian Cancer
CCLE
DSGQNYS
DEG_SCF_TRCP1_1
0.1667
p.E742Q
OVCAR-4
ovary
COSMIC
DSGQNYS
DEG_SCF_TRCP1_1
0.1667
p.S761R
DO42977
UCEC
ICGC
DSGQNYS
DEG_SCF_TRCP1_1
0.1389
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Drug responses associated with IFT88 mutations
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Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of DSGQNYS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q13099
Intraflagellar transport protein 88 homolog
DEG_SCF_TRCP1_1
748:754
DSGQNYS
BTRC
0.9498
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