DegronMD

Uniprot ID: Q13099

Source protein: Intraflagellar transport protein 88 homolog

Source gene: IFT88

Class: DEG_SCF_TRCP1_1

Location: 748:754

E3 ligase: BTRC

DEGRON score: 0.9498

ASA_SCORE: 76.8143

COIL: 0.753

CONS_SCORE: 0.29

DSS_SCORE: 0.662

HELIX: 0.211

FCONS_SCORE: 0.9752

RIG_SCORE: 0.5569

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G759S	TCGA-CG-5728	STAD	TCGA	DSGQNYS	DEG_SCF_TRCP1_1	0.1944
p.R747C	DO230342	COCA	ICGC	DSGQNYS	DEG_SCF_TRCP1_1	0.3056
p.G752W	DO229024	LICA	ICGC	DSGQNYS	DEG_SCF_TRCP1_1	0.7825
p.L744F	DO228371	MALY	ICGC	DSGQNYS	DEG_SCF_TRCP1_1	0.6667
p.S761R	DO42977	UCEC	ICGC	DSGQNYS	DEG_SCF_TRCP1_1	0.1389
p.S743I	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	DSGQNYS	DEG_SCF_TRCP1_1	0.1944
p.S743I	NCI-H1299	lung	COSMIC	DSGQNYS	DEG_SCF_TRCP1_1	0.1944
p.E751Q	SIDM00092	Ovarian Carcinoma	GDSC	DSGQNYS	DEG_SCF_TRCP1_1	0.6744
p.E751Q	OVCAR-4	ovary	COSMIC	DSGQNYS	DEG_SCF_TRCP1_1	0.6744
p.S755T	SIDM00092	Ovarian Carcinoma	GDSC	DSGQNYS	DEG_SCF_TRCP1_1	0.3056
p.S755T	OVCAR-4	ovary	COSMIC	DSGQNYS	DEG_SCF_TRCP1_1	0.3056
p.E742Q	ACH-000617	Ovarian Cancer	CCLE	DSGQNYS	DEG_SCF_TRCP1_1	0.1667
p.E742Q	OVCAR-4	ovary	COSMIC	DSGQNYS	DEG_SCF_TRCP1_1	0.1667
p.S746T	ACH-000617	Ovarian Cancer	CCLE	DSGQNYS	DEG_SCF_TRCP1_1	0.2778
p.S746T	OVCAR-4	ovary	COSMIC	DSGQNYS	DEG_SCF_TRCP1_1	0.2778
p.G747D	ACH-001031	Rhabdoid	CCLE	DSGQNYS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13099	Intraflagellar transport protein 88 homolog	DEG_SCF_TRCP1_1	748:754	DSGQNYS	BTRC	0.9498	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons