DegronMD - Q13136(PPFIA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G524D	TCGA-A3-3320	KIRC	TCGA	GRPHLGSVP	DEG_APCC_DBOX_1	524:532	Mutation altering degron motif	0.6087
p.V531I	TCGA-E6-A2P8	UCEC	TCGA	GRPHLGSVP	DEG_APCC_DBOX_1	524:532	Mutation altering degron motif	0.5965
p.V531I	DO40924	UCEC	ICGC	GRPHLGSVP	DEG_APCC_DBOX_1	524:532	Mutation altering degron motif	0.5965
p.R525Q	TCGA-FI-A2D0	UCEC	TCGA	GRPHLGSVP	DEG_APCC_DBOX_1	524:532	Mutation altering degron motif	0.7329
p.R525Q	DO43891	UCEC	ICGC	GRPHLGSVP	DEG_APCC_DBOX_1	524:532	Mutation altering degron motif	0.7329
p.R515K	DO11854	GBM	ICGC	GRPHLGSVP	DEG_APCC_DBOX_1	524:532	Mutation rewiring degron network	0.0833
p.D533H	DO227931	PBCA	ICGC	GRPHLGSVP	DEG_APCC_DBOX_1	524:532	Mutation rewiring degron network	0.3056
p.R525L	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	GRPHLGSVP	DEG_APCC_DBOX_1	524:532	Mutation altering degron motif	0.8428
p.R525L	ACH-002101	Lung Cancer	CCLE	GRPHLGSVP	DEG_APCC_DBOX_1	524:532	Mutation altering degron motif	0.8428
p.R525L	EMC-BAC-1	lung	COSMIC	GRPHLGSVP	DEG_APCC_DBOX_1	524:532	Mutation altering degron motif	0.8428
p.P526A	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	GRPHLGSVP	DEG_APCC_DBOX_1	524:532	Mutation altering degron motif	0.6392
p.P526A	ACH-000408	Esophageal Cancer	CCLE	GRPHLGSVP	DEG_APCC_DBOX_1	524:532	Mutation altering degron motif	0.6392
p.P526A	TE-5	oesophagus	COSMIC	GRPHLGSVP	DEG_APCC_DBOX_1	524:532	Mutation altering degron motif	0.6392
p.H523R	SIDM01424	B-Lymphoblastic Leukemia	GDSC	GRPHLGSVP	DEG_APCC_DBOX_1	524:532	Mutation rewiring degron network	0.3056
p.H523R	ACH-000782	Leukemia	CCLE	GRPHLGSVP	DEG_APCC_DBOX_1	524:532	Mutation rewiring degron network	0.3056
p.H523R	ACH-001735	Leukemia	CCLE	GRPHLGSVP	DEG_APCC_DBOX_1	524:532	Mutation rewiring degron network	0.3056
p.L521P	ACH-001518	Endometrial/Uterine Cancer	CCLE	GRPHLGSVP	DEG_APCC_DBOX_1	524:532	Mutation rewiring degron network	0.25

Kaplan plot for PPFIA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPFIA1

UniProt ID: Q13136

Entrez ID: 8500

Protein name: Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPFIA1 in