DegronMD

Uniprot ID: Q13136

Source protein: Liprin-alpha-1

Source gene: PPFIA1

Class: DEG_APCC_DBOX_1

Location: 524:532

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9981

ASA_SCORE: 75.6556

COIL: 0.8834

CONS_SCORE: 0.3774

DSS_SCORE: 0.4058

HELIX: 0.0603

FCONS_SCORE: 0.9967

RIG_SCORE: 0.6279

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G524D	TCGA-A3-3320	KIRC	TCGA	GRPHLGSVP	DEG_APCC_DBOX_1	0.6087
p.V531I	TCGA-E6-A2P8	UCEC	TCGA	GRPHLGSVP	DEG_APCC_DBOX_1	0.5965
p.V531I	DO40924	UCEC	ICGC	GRPHLGSVP	DEG_APCC_DBOX_1	0.5965
p.R525Q	TCGA-FI-A2D0	UCEC	TCGA	GRPHLGSVP	DEG_APCC_DBOX_1	0.7329
p.R525Q	DO43891	UCEC	ICGC	GRPHLGSVP	DEG_APCC_DBOX_1	0.7329
p.R515K	DO11854	GBM	ICGC	GRPHLGSVP	DEG_APCC_DBOX_1	0.0833
p.D533H	DO227931	PBCA	ICGC	GRPHLGSVP	DEG_APCC_DBOX_1	0.3056
p.R525L	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	GRPHLGSVP	DEG_APCC_DBOX_1	0.8428
p.R525L	ACH-002101	Lung Cancer	CCLE	GRPHLGSVP	DEG_APCC_DBOX_1	0.8428
p.R525L	EMC-BAC-1	lung	COSMIC	GRPHLGSVP	DEG_APCC_DBOX_1	0.8428
p.P526A	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	GRPHLGSVP	DEG_APCC_DBOX_1	0.6392
p.P526A	ACH-000408	Esophageal Cancer	CCLE	GRPHLGSVP	DEG_APCC_DBOX_1	0.6392
p.P526A	TE-5	oesophagus	COSMIC	GRPHLGSVP	DEG_APCC_DBOX_1	0.6392
p.H523R	SIDM01424	B-Lymphoblastic Leukemia	GDSC	GRPHLGSVP	DEG_APCC_DBOX_1	0.3056
p.H523R	ACH-000782	Leukemia	CCLE	GRPHLGSVP	DEG_APCC_DBOX_1	0.3056
p.H523R	ACH-001735	Leukemia	CCLE	GRPHLGSVP	DEG_APCC_DBOX_1	0.3056
p.L521P	ACH-001518	Endometrial/Uterine Cancer	CCLE	GRPHLGSVP	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13136	Liprin-alpha-1	DEG_APCC_DBOX_1	524:532	GRPHLGSVP	APC,CDC20,FZR1	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons